Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue.
Fiber-optic endomicroscopy system for high-resolution nonlinear imaging of biological tissue.
复制标题
用于生物组织高分辨率非线性成像的光纤内窥镜系统。
DOI：
10.1109/iembs.2008.4649541
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Li,Xingde
中科院分区：
文献类型：
--
作者：
Wu,Yicong;Xi,Jiefeng;Cobb,MichaelJ;Li,Xingde
A flexible fiber-optic endomicroscopy system was developed for nonlinear optical imaging of biological samples. Double-clad fiber and photonic bandgap fiber were employed in the endomicroscope for femtosecond pulse delivery, dispersion compensation, nonlinear optical signals collection and fast beam scanning. Three-dimensional imaging of biological tissues based on second harmonic generation and two-photon excited fluorescence was performed with the endomicroscope. The depth-resolved imaging results strongly suggest the potential of this flexible fiber-optic microscope system for real-time assessment of both epithelial and stromal structures in luminal organs.
