Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
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DOI：
10.1253/circj.cj-09-0488
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发表时间：
2010-03
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通讯作者：
Tomohide Takaya;H. Wada;T. Morimoto;Yoichi Sunagawa;Teruhisa Kawamura;Rieko Takanabe-Mori;A. Shimatsu;Y. Fujita;Yuko Sato;M. Fujita;Takeshi Kimura;T. Sawamura;K. Hasegawa
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作者：
Tomohide Takaya;H. Wada;T. Morimoto;Yoichi Sunagawa;Teruhisa Kawamura;Rieko Takanabe-Mori;A. Shimatsu;Y. Fujita;Yuko Sato;M. Fujita;Takeshi Kimura;T. Sawamura;K. Hasegawa
凝集素样氧化低密度脂蛋白受体-1 （LOX-1）是氧化应激诱导的多配体受体。然而，它在慢性心力衰竭中的作用尚不清楚。方法与结果采用盐敏感大鼠高血压模型检测左心室LOX-1的表达。与对照组相比，肥厚的左室LOX-1 mRNA水平升高4.7倍，收缩功能下降的左室LOX-1 mRNA水平升高32倍。左室LOX-1 mRNA水平与左室射血分数（EF）降低（r=-0.772）、b型利钠肽（r=0.814）、单核细胞趋化蛋白-1 （r=0.943）、转化生长因子- β (r=0.936)、巨噬细胞标志物F4/80 (r=0.560) mRNA水平升高密切相关。左室收缩功能障碍和肥厚患者血清可溶性LOX-1水平显著升高，且与EF降低显著相关（r=-0.495）。结论：心力衰竭患者左室LOX-1表达显著升高可能导致血清LOX-1水平升高，并可能参与心力衰竭发展过程中的慢性炎症反应。
BACKGROUND Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a multiple ligand receptor induced by oxidative stress. However, its role in chronic heart failure remains unknown. METHODS AND RESULTS The left ventricular (LV) expression of LOX-1 was examined in a salt-sensitive Dahl rat model of hypertension. Compared with controls, LOX-1 mRNA levels increased by 4.7-fold in the LV with hypertrophy, and by 32-fold in the LV with decreased systolic function. LV LOX-1 mRNA levels strongly correlated with the decrease in LV ejection fraction (EF) (r=-0.772), and with increases in the LV mRNA levels of B-type natriuretic peptide (r=0.814), monocyte chemoattractant protein-1 (r=0.943), transforming growth factor-beta(1) (r=0.936), and a macrophage marker, F4/80 (r=0.560). Serum levels of soluble LOX-1 were significantly elevated in patients with LV systolic dysfunction and hypertrophy, and significantly correlated with the decrease in EF (r=-0.495). CONCLUSIONS Marked increase in the LV expression of LOX-1 in failing hearts may contribute to increased serum levels, and might be involved in chronic inflammation during the development of heart failure.