Tau deposition patterns are associated with functional connectivity in primary tauopathies.
Tau deposition patterns are associated with functional connectivity in primary tauopathies.
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DOI：
10.1038/s41467-022-28896-3
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发表时间：
2022-03-15
影响因子：
16.6
通讯作者：
Ewers M
中科院分区：
文献类型：
--
作者：
Franzmeier N;Brendel M;Beyer L;Slemann L;Kovacs GG;Arzberger T;Kurz C;Respondek G;Lukic MJ;Biel D;Rubinski A;Frontzkowski L;Hummel S;Müller A;Finze A;Palleis C;Joseph E;Weidinger E;Katzdobler S;Song M;Biechele G;Kern M;Scheifele M;Rauchmann BS;Perneczky R;Rullman M;Patt M;Schildan A;Barthel H;Sabri O;Rumpf JJ;Schroeter ML;Classen J;Villemagne V;Seibyl J;Stephens AW;Lee EB;Coughlin DG;Giese A;Grossman M;McMillan CT;Gelpi E;Molina-Porcel L;Compta Y;van Swieten JC;Laat LD;Troakes C;Al-Sarraj S;Robinson JL;Xie SX;Irwin DJ;Roeber S;Herms J;Simons M;Bartenstein P;Lee VM;Trojanowski JQ;Levin J;Höglinger G;Ewers M
Tau病理学是4个重复的tauopathies中神经元功能障碍的主要驱动因素，包括皮质 - 基质 - 基质性变性和进行性渐进性上的tau，假定tau在连接的神经元中传播类似prion的神经元，但是Tau传播的机制在很大程度上是在很大程度上弹性的。 - 重复的tauopathies，不仅由神经元，而且由星形胶质和寡头tau的加速度来表征，我们在这里评估连通性是否与4R-TAU沉积模式相关联。 46例临床诊断为4个重复的tauopanties和验尸的患者中，来自两个独立的进行性超跨性麻痹患者样品的验尸型细胞型特异性区域tau评估（n = 97和n = 96）。在4个重复的tauapathies中，tau-pet和验尸后水平的区域间相关性较高。在使用tau-pet，我们进一步发现患者级的tau模式与皮层tau震中的连通性相关。 - 重复的tauopathies。
TAU病理驱动4个重复的tauopathies中的神经元功能障碍。
Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies. Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
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DOI：
10.1016/j.jalz.2015.05.001
发表时间：
2015-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Jagust WJ;Landau SM;Koeppe RA;Reiman EM;Chen K;Mathis CA;Price JC;Foster NL;Wang AY
通讯作者：
Wang AY
影响因子：
29
作者：
Gibbons GS;Lee VMY;Trojanowski JQ
通讯作者：
Trojanowski JQ
影响因子：
14.5
作者：
Franzmeier, Nicolai;Rubinski, Anna;Ewers, Michael
通讯作者：
Ewers, Michael
影响因子：
11.2
作者：
Arai, T;Ikeda, K;Mochizuki, A
通讯作者：
Mochizuki, A
影响因子：
4.8
作者：
Guo, Jing L.;Lee, Virginia M. -Y.
通讯作者：
Lee, Virginia M. -Y.