Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.
Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma.
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DOI：
10.1155/2012/450179
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发表时间：
2012
影响因子：
--
通讯作者：
Lu SL
中科院分区：
文献类型：
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作者：
Du L;Shen J;Weems A;Lu SL
磷脂酰肌醇-3 -激酶（PI3K）通路的激活是许多人类恶性肿瘤中最常观察到的分子改变之一，包括头颈部鳞状细胞癌（HNSCC）。越来越多的证据表明PI3K通路在肿瘤发生的各个阶段，即肿瘤起始、进展、复发和转移中至关重要。不出所料，针对PI3K通路在某些癌症患者的临床前研究和临床试验中都取得了一些有希望的结果。然而，鉴于该通路的复杂性以及其多个反馈回路的存在以及与其他信号通路的相互作用，仍有许多问题需要回答。在本文中，我们将总结在理解PI3K通路在人类恶性肿瘤中的作用方面的最新进展，重点是头颈部鳞状细胞癌，并讨论该领域的临床应用和未来方向。
Activation of the phosphatidylinositol-3-kinase (PI3K) pathway is one of the most frequently observed molecular alterations in many human malignancies, including head and neck squamous cell carcinoma (HNSCC). A growing body of evidence demonstrates the prime importance of the PI3K pathway at each stage of tumorigenesis, that is, tumor initiation, progression, recurrence, and metastasis. Expectedly, targeting the PI3K pathway yields some promising results in both preclinical studies and clinical trials for certain cancer patients. However, there are still many questions that need to be answered, given the complexity of this pathway and the existence of its multiple feedback loops and interactions with other signaling pathways. In this paper, we will summarize recent advances in the understanding of the PI3K pathway role in human malignancies, with an emphasis on HNSCC, and discuss the clinical applications and future direction of this field.