Distress and reduced fertility:: A follow-up study of first-pregnancy planners
Distress and reduced fertility:: A follow-up study of first-pregnancy planners
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DOI：
10.1016/s0015-0282(99)00186-7
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发表时间：
1999-07-01
影响因子：
6.7
通讯作者：
Olsen, J
中科院分区：
文献类型：
--
作者：
Hjollund, NHI;Jensen, TK;Olsen, J
目的：评估心理困扰对首次怀孕时间的影响。设计：一项关于怀孕时间的后续研究，其中包含有关痛苦的前瞻性数据，并控制了潜在的混杂变量。地点：两所大学医院。患者：计划首次怀孕且之前没有生育经验的丹麦夫妇 (n = 430)，对他们进行了六个月经周期的随访。通过一般健康问卷测量每个月经周期的心理困扰。干预措施：无。主要结果测量：临床上认可的妊娠或在每次阴道出血的尿液样本中检测到生化妊娠。结果：对于痛苦评分最高的周期（一般健康问卷评分>第 80 个百分位），每个周期的受孕概率为 12.8%，而其他周期的受孕概率为 16.5%（调整后）比值比 [OR] 0.6；95% 置信区间 [CI] 0.4-1.0）。痛苦的影响几乎只出现在月经周期较长的女性中（对于月经周期大于或等于 35 次的女性，OR 0.1；95% CI 0.01-0.4，OR 0.9；95% CI 0.5-1.4）
Objective: To assess the effect of psychological distress on time to first pregnancy.Design: A follow-up study of time to pregnancy with prospective data on distress, with controlling for potential confounding variables.Setting: Two university hospitals.Patient(s): Danish couples (n = 430) who were planning their first pregnancy and had no previous reproductive experience were followed for six menstrual cycles. Psychological distress was measured in each menstrual cycle by the General Health Questionnaire.Intervention(s): None.Main Outcome Measure(s): A clinically recognized pregnancy or a biochemical pregnancy detected in urine samples from each period of vaginal bleeding.Result(s): For cycles with the highest distress score (General Health Questionnaire score >80th percentile), the probability of conception per cycle was 12.8%, compared with 16.5% in other cycles (adjusted odds ratio [OR] 0.6; 95% confidence interval [CI] 0.4-1.0). The effect of distress was found almost exclusively among women with long menstrual cycles (OR 0.1; 95% CI 0.01-0.4 and OR 0.9; 95% CI 0.5-1.4 for women with cycles of greater than or equal to 35 and