Study of elastic collisions of Myxococcus xanthus in swarms
Study of elastic collisions of Myxococcus xanthus in swarms
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DOI：
10.1088/1478-3975/8/2/026016
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发表时间：
2011-04-01
期刊：
影响因子：
2
通讯作者：
Alber, Mark
中科院分区：
文献类型：
--
作者：
Harvey, Cameron W.;Morcos, Faruck;Alber, Mark
在非常低密度的情况下，单个粘细菌细胞与其他细胞不直接接触，粘液胶囊与基质或基质上的粘液轨迹相互作用产生粘性阻力，从而导致平滑的滑动运动。结合基于细胞的三维计算模型和细胞跟踪实验，研究了靠近群边缘的低密度域中粘细菌细胞的粘弹性相互作用。该模型考虑了黄色粘球菌的灵活性，以及覆盖两个相互接触的细胞的荚膜多糖相互作用所产生的细胞间粘附的影响。新的图像和动态细胞曲率分析算法用于跟踪和测量柔性细胞在碰撞过程中经历显着弯曲时发生的细胞形状变化，从而直接校准模型参数。与纵横比和方向反转一样，M. xanthus 的细胞灵活性以及粘附细胞与细胞和细胞与基质的相互作用在平滑滑行和更有效的集群中发挥着重要作用。
In very low density situations where a single myxobacterial cell is isolated from direct contact with other cells, the slime capsule interaction with the substrate or slime tracks on the substrate produce a viscous drag that results in a smooth gliding motion. Viscoelastic interactions of myxobacteria cells in a low-density domain close to the edge of a swarm are studied using a combination of a cell-based three-dimensional computational model and cell-tracking experiments. The model takes into account the flexible nature of Myxococcus xanthus as well as the effects of adhesion between cells arising from the interaction of the capsular polysaccharide covering two cells in contact with each other. New image and dynamic cell curvature analysis algorithms are used to track and measure the change in cell shapes that occur as flexible cells undergo significant bending during collisions resulting in direct calibration of the model parameters. Like aspect-ratio and directional reversals, the flexibility of cells and the adhesive cell-cell and cell-substrate interactions of M. xanthus play an important role in smooth gliding and more efficient swarming.