Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction.
Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction.
复制标题
铁过载引起的最早的心脏毒性选择性地抑制电传导。
DOI：
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发表时间：
2002
影响因子：
3.3
通讯作者：
W. Braselton
中科院分区：
文献类型：
--
作者：
K. Schwartz;Zy Li;D. Schwartz;T. G. Cooper;W. Braselton
Female guinea pigs were injected intraperitoneally with 0.083 g/kg iron dextran (Fe-D) to achieve progressively increasing levels of iron load; controls received dextran. Delayed and blocked cardiac conductivity at the Purkinje fiber-papillary muscle junction was initially observed with Fe-D loads of 0.33 g/kg. Serial magnetic resonance relaxation time measurements obtained from livers of live animals showed a decrease (8.1 +/- 0.86 vs. 14.8 +/- 1.03 ms in controls, P < 0.001) that was first observed in animals loaded with 0.25 g/kg Fe-D. Iron concentrations in hearts and livers were significantly increased (P < 0.001). Left ventricular pressure measurements on 1.5 g/kg Fe-D animals failed to demonstrate a defect in contractility, but 27% (9/33) (P < 0.050) of the animals died without warning signs. We conclude that 1) initial decreases in liver magnetic resonance-relaxation time occur in the same range of iron excess as the threshold of iron load that induces delay or blockade of cardiac conduction and 2) a high incidence of sudden death, presumably from cardiac arrhythmias, was observed with large doses of iron that did not decrease left ventricular contractility.
β-地中海贫血的螯合疗法：去铁胺的益处和局限性。
影响因子：
3.6
作者：
Giardina,PJ;Grady,RW
通讯作者：
Grady,RW
影响因子：
158.5
作者：
BRITTENHAM, GM;GRIFFITH, PM;HARRIS, JW
通讯作者：
HARRIS, JW
影响因子：
37.8
作者：
Kuryshev, YA;Brittenham, GM;Brown, AM
通讯作者：
Brown, AM