Impaired insulin secretion after oral sucrose and fructose in rats.
Impaired insulin secretion after oral sucrose and fructose in rats.
复制标题
大鼠口服蔗糖和果糖后胰岛素分泌受损。
作者：
E. Hara;M. Saito
在未麻醉、不受约束的大鼠中检查了蔗糖和果糖对血浆葡萄糖和胰岛素对口服和/或静脉注射葡萄糖的反应的影响。尽管血浆葡萄糖对口服蔗糖或葡萄糖和果糖混合物的反应相似，但血浆胰岛素对口服蔗糖或葡萄糖和果糖混合物的反应远低于对口服葡萄糖的反应。口服果糖对静脉输注葡萄糖的胰岛素反应没有影响。静脉输注果糖也不影响血浆葡萄糖和胰岛素对口服葡萄糖的反应。口服果糖对口服葡萄糖的胰岛素反应的抑制作用可以通过口服大豆油逆转，已知大豆油可以刺激静脉注射葡萄糖诱导的胰岛素分泌。我们得出的结论是，果糖对胰岛素分泌的抑制作用是由胃肠道中产生的一些信号介导的。
The effects of sucrose and fructose on responses in plasma glucose and insulin to glucose given orally and/or iv were examined in unanesthetized, unrestrained rats. The plasma insulin response to oral administration of sucrose or a mixture of glucose and fructose was much lower than that to oral glucose despite the fact that plasma glucose responses to these administrations were similar. Oral administration fructose had no effect on the insulin response to iv infusion of glucose. Intravenous infusion of fructose also did not affect the plasma glucose and insulin responses to oral administration of glucose. The inhibitory effect of oral fructose on the insulin response to oral glucose was reversed by oral administration of soybean oil, which is known to stimulate insulin secretion induced by iv glucose. We conclude that the inhibitory effect of fructose on insulin secretion is mediated by some signals generated in the gastrointestinal tract.