Aversive stimuli bias corticothalamic responses to motivationally significant cues.
Aversive stimuli bias corticothalamic responses to motivationally significant cues.
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DOI：
10.7554/elife.57634
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发表时间：
2021-11-05
期刊：
影响因子：
7.7
通讯作者：
Cohen JY
中科院分区：
文献类型：
--
作者：
Lucantonio F;Kim E;Su Z;Chang AJ;Bari BA;Cohen JY
预测未来的奖励或惩罚是适应行为的基础。这些过程受到先前经验的影响。例如，先前暴露于令人厌恶的刺激或压力源会改变对消极和积极价值预测线索的行为反应。在这里，我们证明了内侧前额叶皮层（mPFC）神经元投射到丘脑室旁核（PVT; mPFC→PVT）在这个过程中的作用。我们发现，在小鼠中，厌恶性刺激的历史会使其对动机相关线索的行为反应产生负性偏差，并且这种负性偏差与暴露于这些线索期间mPFC→PVT神经元的过度活跃有关。此外，人工模拟这种过度活跃的反应，选择性光遗传学激发相同的途径，重演了由厌恶刺激诱导的负性行为偏差，而mPFC→PVT神经元的光遗传学失活阻止了负性偏差的发展。总之，我们的研究结果强调了mPFC→PVT回路中的信息流对于根据先前经验预测动机相关结果至关重要。
Making predictions about future rewards or punishments is fundamental to adaptive behavior. These processes are influenced by prior experience. For example, prior exposure to aversive stimuli or stressors changes behavioral responses to negative- and positive-value predictive cues. Here, we demonstrate a role for medial prefrontal cortex (mPFC) neurons projecting to the paraventricular nucleus of the thalamus (PVT; mPFC→PVT) in this process. We found that a history of aversive stimuli negatively biased behavioral responses to motivationally relevant cues in mice and that this negative bias was associated with hyperactivity in mPFC→PVT neurons during exposure to those cues. Furthermore, artificially mimicking this hyperactive response with selective optogenetic excitation of the same pathway recapitulated the negative behavioral bias induced by aversive stimuli, whereas optogenetic inactivation of mPFC→PVT neurons prevented the development of the negative bias. Together, our results highlight how information flow within the mPFC→PVT circuit is critical for making predictions about motivationally-relevant outcomes as a function of prior experience.