Keratinocyte HLA‐DR expression: the relationship to dermal lymphocytic infiltration
Keratinocyte HLA‐DR expression: the relationship to dermal lymphocytic infiltration
复制标题
角质形成细胞 HLA-DR 表达：与真皮淋巴细胞浸润的关系
DOI：
10.1111/j.1365-2230.1987.tb01934.x
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发表时间：
1987
影响因子：
4.1
通讯作者：
D. Macdonald
中科院分区：
文献类型：
--
作者：
J. Barker;J. Ophir;D. Macdonald
Several cutaneous disorders are characterized by keratinocyte expression of HLA‐DR. Using an immunohistochemical assay we have observed that expression is maximal where the dermal lymphocytic infiltrate is most intense. This finding is consistent with induction of keratinocyte HLA‐DR expression by gamma‐interferon, released by activated T‐lymphocytes. In atopic dermatitis and psoriasis, where T‐lymphocytes are also observed within the infiltrate, keratinocytes do not express HLA‐DR.
