Slow thrombin is zymogen-like.
Slow thrombin is zymogen-like.
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DOI：
10.1111/j.1538-7836.2009.03365.x
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Huntington JA
中科院分区：
文献类型：
--
作者：
Huntington JA
Blood coagulation is the result of a cascade of zymogen activation events, however, its initiation is allosteric. Factor VIIa circulates in a zymogen-like state and is allosterically activated by binding to tissue factor. Thrombin, the final protease generated in the blood coagulation cascade, has also been shown to exist in a low activity state in the absence of cofactors, and the structural features of this ‘slow’ form has been studied for many years. In this manuscript I will review the general features that render zymogens inactive and how proteolytic cleavage results in activation, but I will also show how this distinction is blurred by zymogens that have activity (protease-like zymogens) and proteases with low activity (zymogen-like proteases). This will then be applied in the analysis of slow thrombin to reveal how allosteric activation of thrombin simply reflects the conversion from a zymogen-like enzyme to an active serine protease.
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DOI：
10.1073/pnas.69.11.3312
发表时间：
1972-01-01
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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