Amyloidosis of a possible new type in patients receiving long-term hemodialysis.
Amyloidosis of a possible new type in patients receiving long-term hemodialysis.
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接受长期血液透析的患者可能出现新型淀粉样变性。
DOI：
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发表时间：
1985
影响因子：
4.6
通讯作者：
Y. Hirasawa
中科院分区：
文献类型：
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作者：
T. Morita;M. Suzuki;A. Kamimura;Y. Hirasawa
6例接受长期（12 ~ 17年）血液透析的患者发生腕管综合征。肌腱和滑膜-肌腱鞘的活检标本显示嗜酸性透明蛋白沉积，具有淀粉样蛋白的许多特性。然而，除了P成分外，这种材料不能与已知淀粉样蛋白的抗体发生反应。在电子显微镜下，该材料由9 ~ 10nm厚的细丝组成，这些细丝表现出明显的平行排列和束状排列趋势。在接受检查的四名患者中，有三名在直肠小动脉中发现了同样的物质。我们认为这种物质代表了一种以前未描述过的淀粉样蛋白。它的沉积可能是由于长期血液透析的影响，也可能是由于长期尿毒症状态，并可能对透析患者构成潜在的问题。
Carpal tunnel syndrome developed in six patients receiving long-term (12 to 17 years) hemodialysis. Biopsy specimens of tendons and synovial-tendon sheaths showed deposition of eosinophilic hyalin material exhibiting many properties of amyloid. However, this material did not react with antibodies to known amyloid proteins, except for the P component. On electron microscopy, the material consisted of fine filaments, 9 to 10 nm thick, that showed a marked tendency to parallel alignment and arrangement in bundles. The same material was found in arterioles of the rectum in three of four patients who were examined. We suggest that this material represents a previously undescribed type of amyloid. Its deposition may be due to the effects of long-term hemodialysis, or to the long-term uremic state, and may pose a potential problem to dialyzed patients.