Quantitative Analysis of Protein Transport in the Arterial Wall
Quantitative Analysis of Protein Transport in the Arterial Wall
复制标题
动脉壁中蛋白质转运的定量分析
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
K. Smith
中科院分区：
文献类型：
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作者：
G. Truskey;C. Colton;K. Smith
蛋白质在血管壁中的转运和积累在生理学上是重要的，并且可能在某些疾病状态的发病机制中起作用。通过限制血浆蛋白（主要是白蛋白）穿过毛细血管壁的转运来维持血浆渗透压。脂蛋白也可以穿过毛细血管壁，从而将胆固醇从肝脏运送到身体的其他部位。如纯合子家族性高胆固醇血症，肝外组织对脂蛋白的摄取减少，导致血浆中脂蛋白浓度升高，这可能导致动脉粥样硬化发生率增加。动脉粥样硬化本身与动脉壁胆固醇的异常积聚有关。实验证据表明，这种胆固醇来源于血浆中的脂蛋白，特别是低密度脂蛋白（LDL）（Zilversmit，1968; Smith和斯莱特，1970;代顿和桥本，1970）。
The transport and accumulation of proteins in blood vessel walls is important physiologically and may play a role in the pathogenesis of certain disease states. Plasma osmotic pressure is maintained by limiting the transport of plasma proteins, chiefly albumin, across the capillary wall. Lipoproteins may also pass across capillary walls and thus carry cholesterol from the liver to the rest of the body. Abnormalities in lipoprotein uptake by extrahepatic tissue, as in homozygous familial hypercholesterolemia, lead to elevated lipoprotein concentrations in the plasma which may result in increased incidence of atherosclerosis. Atherosclerosis itself is associated with the abnormal accumulation of cholesterol in the arterial wall. Experimental evidence indicates that this cholesterol is derived from lipoproteins, in particular low-density lipoprotein (LDL), in the plasma (Zilversmit, 1968; Smith and Slater, 1970; Dayton and Hashimoto, 1970).
体内血小板粘附到兔胸主动脉暴露的内皮下的形态学和形态测量特征。
影响因子：
3.1
作者：
Ramírez,CA;Stemerman,MB;Isaacson,KA;Colton,CK;Smith,KA;Lees,RS
通讯作者：
Lees,RS