MORPHOLOGIC TYPES OF BREAST-CANCER - AGE, BILATERALITY, AND FAMILY HISTORY
MORPHOLOGIC TYPES OF BREAST-CANCER - AGE, BILATERALITY, AND FAMILY HISTORY
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DOI：
10.1097/00007611-198001000-00012
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发表时间：
1980-01-01
影响因子：
1.1
通讯作者：
HOGE, AF
中科院分区：
文献类型：
--
作者：
ERDREICH, LS;ASAL, NR;HOGE, AF
形态学类型通常不包括在癌症危险因素的研究中。在乳腺癌中，人们正在关注诊断时的年龄。在这项研究中，通过形态学类型以及诊断时的年龄对病例进行分析，以了解双侧疾病的发生情况和乳腺癌家族史。在年轻患者中更常见的形态学类型-原位小叶、髓样和导管内粉刺-只有原位小叶的双侧性频率增加（增加4倍）。其中，只有导管内粉刺的患者报告家族性乳腺癌的频率高于平均水平。小叶浸润性癌在老年患者中更常见，与2.6倍的双侧性和增加的家族风险相关。45 - 54岁诊断也与双侧性增加相关，但小叶癌的诊断与双侧性的相关性比早期诊断更强。由于双侧小叶性肿瘤和绝经前有癌症家族史的女性双侧小叶性肿瘤的风险较高，因此应在这些女性中进行双侧活检和随后的恶性肿瘤筛查。
Morphologic type is not generally included in the study of cancer risk factors. In breast cancer, attention is being given to age at diagnosis. In this study cases were analyzed by morphologic type as well as age at diagnosis for occurrence of bilateral disease and for family history of breast cancer. Of the morphologic types which were more frequent in younger patients--lobular in situ, medullary, and intraductal comedo--only lobular in situ had an increased frequency of bilaterality (fourfold increase). Of these, only patients with intraductal comedo reported familial breast cancer more frequently than the average. Lobular infiltrating carcinoma is diagnosed more frequently in elderly patients and is associated with 2.6 times more bilaterality and increased familial risk. Diagnosis at age 45 to 54 is also associated with increased bilaterality, but the diagnosis of lobular carcinoma has much stronger association with bilaterality than early age at diagnosis. Because of the high risk of bilaterality in lobular neoplasia and in those with a family history of cancer occurring before the menopause, bilateral biopsies and subsequent screening for malignancy should be done in these women.