Rapid synthesis of nontoxic and photostable carbon nanoparticles for bioimaging applications
Rapid synthesis of nontoxic and photostable carbon nanoparticles for bioimaging applications
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DOI：
10.1016/j.matlet.2019.127012
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发表时间：
2020-02-15
影响因子：
3
通讯作者：
Atabaev, Timur Sh
中科院分区：
文献类型：
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作者：
Molkenova, Anara;Toleshova, Aidana;Atabaev, Timur Sh
本研究采用水热法在较短的时间内(t=30min)合成了量子产率为6.08%的荧光碳纳米颗粒。荧光光谱分析表明，碳纳米管具有良好的光稳定性，适合长时间的生物成像应用。对L-929成纤维细胞的细胞毒性研究表明，制备的CNPS在较高浓度下也是无毒的，最高可达250微克/毫升，从L-929细胞中观察到强烈的绿色荧光信号，表明CNPS可用于体外组织/细胞生物成像。(C)2019爱思唯尔B.V.保留所有权利。
In this study, fluorescent carbon nanoparticles (CNPs) with quantum yield of 6.08% have been synthesized using a hydrothermal method within a short period of time (t = 30 min). Fluorescence spectroscopy (FS) revealed that CNPs demonstrate excellent photostability which is suitable for prolonged bioimaging applications. Cytotoxicity study with L-929 fibroblastic cells showed that prepared CNPs are nontoxic even at relatively high concentrations up to 250 mu g/ml. Strong green fluorescence signal observed from L-929 cells suggested that CNPs can be utilized for in-vitro tissues/cells bioimaging applications. (C) 2019 Elsevier B.V. All rights reserved.