FOOD-RESTRICTING 1ST GENERATION JUVENILE FEMALE HAMSTERS (MESOCRICETUS-AURATUS) AFFECTS SEX-RATIO AND GROWTH OF 3RD GENERATION OFFSPRING
FOOD-RESTRICTING 1ST GENERATION JUVENILE FEMALE HAMSTERS (MESOCRICETUS-AURATUS) AFFECTS SEX-RATIO AND GROWTH OF 3RD GENERATION OFFSPRING
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DOI：
10.1095/biolreprod37.3.612
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发表时间：
1987-10-01
影响因子：
3.6
通讯作者：
LISK, RD
中科院分区：
文献类型：
--
作者：
HUCK, UW;LABOV, JB;LISK, RD
雌性仓鼠（第1代）在其出生后的前50天内自由采食或限制进食至对照组消耗量的65-75%。受试者在91日龄时交配。在整个实验过程中，它们的后代（第2代）自由采食，雌性后代也在91日龄时交配。从出生至分娩后第25天，每5天监测第3代窝仔的窝仔数、性别比和幼仔体重。尽管出生时第3代窝仔数无显著差异，但第5-25天，限食第1代雌性动物（R组）的后代窝仔显著小于对照第1代雌性动物（A组）的后代窝仔。从出生到第25天，A组窝仔的性别比仍显著高于R组窝仔，但未随时间变化，表明雄性和雌性幼仔的产后死亡率相似。在治疗期间，第3代雄性和雌性幼崽的体重在任何时候都没有显着变化。从出生到第25天，A组雄性动物的体重显著高于R组雄性动物，但A组和R组雌性动物的体重始终相似。早期的食物限制可能会对仓鼠后代的性别比例产生长期影响。
Female hamsters (Generation 1) were fed ad libitum or were food-restricted to 65-75% of the amount consumed by controls during their first 50 days of life. Subjects were mated at 91 days of age. Their offspring (Generation 2) were fed ad libitum throughout the experiment, and female offspring were also mated at 91 days of age. Generation 3 litters were monitored every fifth day from birth until Day 25 post partrum for litter size, sex ratio, and pup weights. Although there were no significant differences in Generation 3 litter sizes at birth, litters descended from food-restricted Generation 1 females (Group R) were significantly smaller on Days 5-25 than litters descended from control Generation 1 females (Group A). Sex ratios remained significantly greater in Group A than in Group R litters from birth to Day 25 but did not vary over time, suggesting similar postpartum mortality rates for both male and female pups. Weights of Generation 3 male and female pups did not vary significantly within treatments at any time. Group A males weighed significantly more than Group R males from birth through Day 25, but weights of Group A and Group R females were always similar. Food restriction early in life may have long-term consequences on sex ratios of subsequent generations in hamsters.