Drug resistance models for malaria
Drug resistance models for malaria
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DOI：
10.1016/j.actatropica.2005.04.006
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发表时间：
2005-06-01
期刊：
影响因子：
2.7
通讯作者：
Mackinnon, MJ
中科院分区：
文献类型：
--
作者：
Mackinnon, MJ
根据理论模型，综述了影响疟疾耐药性演变的主要因素。对耐药性的出现和传播速度产生压倒性影响的是接受药物治疗的受感染宿主的比例。第二个重要的作用是药物杀灭寄生虫的功效。平均传播率、重组、耐药性的生物成本和基因作用方式等因素也会影响传播速度，但影响相对较小。为了说明主要结论，提出了一个简单的种群动态模型，该模型捕捉了药物治疗和耐药性的流行病学影响，而不是种群遗传学模型。(c) 2005 Elsevier B.V.版权所有
The main factors affecting the evolution of drug resistance in malaria according to theoretical models are reviewed here. The overwhelming influence on the emergence and rate of spread of drug resistance is the proportion of infected hosts that are treated with drugs. A second important effect is drug efficacy in killing parasites. Factors such as average transmission rate, recombination, the biological cost of resistance, and the mode of gene action also influence the rate of spread but have relatively minor impacts. A simple population dynamics model that captures the epidemiological effects of drug treatment and resistance, as opposed to a population genetics model that does not, is presented in order to illustrate the main conclusions. (c) 2005 Elsevier B.V. All rights reserved.