Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: Part I, functional assessment
Dynamic contrast-enhanced MR urography in the evaluation of pediatric hydronephrosis: Part I, functional assessment
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DOI：
10.2214/ajr.04.1540
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发表时间：
2005-12-01
影响因子：
5
通讯作者：
Grattan-Smith, JD
中科院分区：
文献类型：
--
作者：
Jones, RA;Easley, K;Grattan-Smith, JD
客观的。我们研究的目的是从 3D 动态 MR 尿路造影得出肾皮质和髓质的时间-强度曲线，并评估这些曲线是否可以预测梗阻。材料和方法。对 53 名儿童患者进行了 59 次检查，并使用肾传输时间评估梗阻程度。使用半自动方法对皮质和髓质进行分割，并导出分割体积的平均时间-强度曲线。评估曲线的基本参数（幅度、冲刷），以及曲线的某些特征的存在。结果。这些图像可以清晰地显示皮质、髓质和收集系统中对比材料摄取的三个阶段。曲线的幅度和对比材料的冲刷都预示着阻塞。在无阻塞肾脏的皮质中可靠地检测到远端管状峰。 结论。将信号强度与时间曲线分析与可从同一 MR 尿路造影数据集导出的其他参数相结合，为梗阻诊断提供了强大的工具。
OBJECTIVE. The purpose of our study was to derive time-intensity curves for the renal cortex and medulla from 3D dynamic MR urography and to assess whether these curves are predictive of obstruction.MATERIALS AND METHODS. Fifty-nine examinations were performed in 53 pediatric patients and the degree of obstruction assessed using the renal transit time. The cortex and medulla were segmented using a semiautomatic method, and mean time-intensity curves were derived for the segmented volumes. The basic parameters of the curves (amplitude, washout) were assessed, as was the presence of certain characteristic features of the curves.RESULTS. The images allowed clear visualization of three phases of the uptake of contrast material in the cortex, the medulla, and the collecting system. Both the amplitude of the curves and the washout of the contrast material were predictive of obstruction. The distal tubular peak was reliably detected in the cortex of nonobstructed kidneys.CONCLUSION. Combining signal-intensity-versus-time-curve analysis with the other parameters that can be derived from the same MR urography data set provides a powerful tool for the diagnosis of obstruction.