Extracellular vesicles: biology and emerging therapeutic opportunities
Extracellular vesicles: biology and emerging therapeutic opportunities
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DOI：
10.1038/nrd3978
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发表时间：
2013-05-01
影响因子：
120.1
通讯作者：
Wood, Matthew J. A.
中科院分区：
文献类型：
--
作者：
EL Andaloussi, Samir;Maeger, Imre;Wood, Matthew J. A.
在过去的十年中，细胞外囊泡已经成为细胞间通讯的重要介质，参与原核生物和高等真核生物细胞之间的生物信号传递，以调节各种生物过程。此外，细胞外囊泡的病理生理作用开始在包括癌症、传染病和神经退行性疾病在内的疾病中得到认识，突出了治疗干预的潜在新靶点。此外，未修饰的和工程化的细胞外囊泡都可能在大分子药物递送中具有应用。在这里，我们回顾了最近的进展，了解细胞外囊泡生物学和细胞外囊泡在疾病中的作用，讨论新兴的治疗机会，并考虑相关的挑战。
Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macro-molecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.