Elevated nonprotein-bound cortisol (NPC) in pregnancy, during estrogen administration and in carcinoma of the prostate.
Elevated nonprotein-bound cortisol (NPC) in pregnancy, during estrogen administration and in carcinoma of the prostate.
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怀孕期间、服用雌激素期间和前列腺癌期间非蛋白质结合皮质醇 (NPC) 升高。
DOI：
10.1210/jcem-29-6-757
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发表时间：
1969
期刊：
影响因子：
--
通讯作者：
U. Seal
中科院分区：
文献类型：
--
作者：
R. Doe;P. Dickinson;H. Zinneman;U. Seal
摘要 研究发现，妊娠期间上午 9 点和晚上 9 点非蛋白质结合皮质醇 (NPC) 会升高。雌性服用雌激素后，NPC 仅在上午 9 点升高。实验值和计算值之间非常吻合。怀孕期间存在皮质醇型氨基酸尿症（组氨酸、丙氨酸、苏氨酸、天冬酰胺/谷氨酰胺和丝氨酸升高），这为 NPC 浓度升高的重要性提供了生理学支持。雌激素治疗后，仅组氨酸和苏氨酸的排泄量升高。怀孕期间 NPC 浓度升高可能解释了在这种情况下有时会出现库欣样状态，而男性服用雌激素后正常的晚上 9 点 NPC 可能有助于解释库欣样状态的缺失。在正常血清中添加妊娠期正常浓度的黄体酮不会导致 NPC 的相应增加。无症状前列腺癌患者的 NPC 升高。
Abstract Nonprotein-bound cortisol (NPC) was found to be elevated in pregnancy at 9 AM and 9 PM. Following estrogen administration, to females, NPC was elevated at 9 AM only. Excellent agreement was found between experimental and calculated values. A cortisol-type aminoaciduria (elevated histidine, alanine, threonine, asparagine/glutamine and serine) was present during pregnancy, giving physiological support to the significance of the elevated NPC concentrations. Following estrogen treatment only histidine and threonine excretions were elevated. The elevated NPC concentration in pregnancy may explain the Cushingoid state sometimes present in that condition, whereas the normal 9 pm NPC following estrogen in males may help explain the absence of a Cushingoid state. Addition of progesterone to normal serum in the concentration normally found in pregnancy did not cause a comparable increase in NPC. Patients with asymptomatic carcinoma of the prostate had elevated NPC.