Design of pH-dependent DNA Cleavage Agents Activated through Ring Contraction Rearrangement
Design of pH-dependent DNA Cleavage Agents Activated through Ring Contraction Rearrangement
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通过环收缩重排激活的 pH 依赖性 DNA 切割剂的设计
DOI：
10.1039/c3cc39246e
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Kiyosei Takasu
中科院分区：
文献类型：
--
作者：
Yuuki Nagamoto;Akira Hattori;Hideaki Kakeya;Yoshiji Takemoto;Kiyosei Takasu
苯并稠合环丁醇是一种新型的DNA切割分子。这些分子在酸性条件下会使超螺旋DNA链产生缺口。相比之下，在中性或碱性条件下几乎没有观察到活性。
Benzo-fused cyclobutanols were developed as novel DNA cleaving molecules. The molecules nick a strand of supercoiled DNA under acidic conditions. By contrast, almost no activity was observed under neutral or basic conditions.