Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment
Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment
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DOI：
10.1037/0894-4105.22.2.177
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发表时间：
2008-03-01
期刊：
影响因子：
2.4
通讯作者：
Graham, Simon J.
中科院分区：
文献类型：
--
作者：
Anderson, Nicole D.;Jennings, Janine M.;Graham, Simon J.
记忆障碍与遗忘性轻度认知障碍(AMCI)相关的认知机制目前知之甚少。我们调查了27名健康的年轻人、45名健康的老年人和17名AMCI患者的回忆和熟悉程度。与年轻人相比，老年人的记忆力下降，尤其是在患有急性MCI的患者中。熟悉度在不同的群体中没有差异。在健康的年轻人和老年人中，在一套对内侧颞叶功能敏感的临床记忆测量中表现更好的人，与更好的记忆力有关。此外，在健康的老年人中，更好的执行功能也与更好的记忆力有关。这些结果与以下观点是一致的，即回忆是由前额叶皮质调节的策略性过程的产物，该过程支持从海马体提取上下文相关记忆。与脑梗塞相关的海马区萎缩可能会破坏这一大脑网络，从而干扰记忆。
Little is known about the cognitive mechanisms of the memory impairment associated with amnestic mild cognitive impairment (aMCI). We explored recollection and familiarity in 27 healthy young adults, 45 healthy older adults, and 17 individuals with aMCI. Relative to the younger adults, recollection was reduced in the older adults, especially among those with aMCI. Familiarity did not differ among groups. In the healthy younger and older adults, better performance on a set of clinical memory measures that are sensitive to medial temporal lobe functioning was associated with greater recollection. In addition, among the healthy older adults better executive functioning was also associated with greater recollection. These results are consistent with the notion that recollection is a product of strategic processes mediated by the prefrontal cortex that suppport the retrieval of context-dependent memories from the hippocampus. Hippocampal atrophy associated with aMCI may disrupt this brain network, and thereby interfere with recollection.