Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.
Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets.
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DOI：
10.14694/edbk_175561
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Rathmell, W Kimryn
中科院分区：
文献类型：
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作者：
Weyandt, Jamie D;Thompson, Craig B;Rathmell, W Kimryn
20世纪20年代，奥托·瓦尔堡发现，肿瘤细胞比正常细胞吸收更多的葡萄糖，产生更多的乳酸盐，这为癌细胞重新编程代谢提供了第一条线索。然而，多年来，人们并不清楚这些代谢改变是肿瘤生长的结果，还是为这些细胞提供生存优势的适应。近年来，对癌细胞代谢差异的兴趣激增，因为肿瘤增殖和存活已被证明依赖于这些代谢变化。在这篇教育综述中，我们讨论了肿瘤细胞用于重新编程其代谢以提供快速或持续增殖所需的能量和营养的一些机制，并讨论了这些途径的治疗靶向改善患者预后的潜力。
Otto Warburg's discovery in the 1920s that tumor cells took up more glucose and produced more lactate than normal cells provided the first clues that cancer cells reprogrammed their metabolism. For many years, however, it was unclear as to whether these metabolic alterations were a consequence of tumor growth or an adaptation that provided a survival advantage to these cells. In more recent years, interest in the metabolic differences in cancer cells has surged, as tumor proliferation and survival have been shown to be dependent upon these metabolic changes. In this educational review, we discuss some of the mechanisms that tumor cells use for reprogramming their metabolism to provide the energy and nutrients that they need for quick or sustained proliferation and discuss the potential for therapeutic targeting of these pathways to improve patient outcomes.