The effect of androgen on spermatogenesis.
The effect of androgen on spermatogenesis.
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雄激素对精子发生的影响。
作者：
Dorothy Jensen Ludwig
引言1雄性激素对大鼠睾丸重量和精子发生的抑制作用已经被许多工作者在不同年龄的动物中使用大范围剂量的雄激素所报道。然而，结果的趋势表明，小剂量雄激素（0.1至1.0 mg.每天）比大剂量（2.0至10.0 mg.（摩尔和普莱斯，1937，1938;塞尔和弗里德曼，1941;扎勒，1944;以及这些论文的参考书目中列出的许多其他参考文献）。对大鼠给予雌激素物质同样会严重抑制睾丸功能，如果同时注射雄激素，则可以预防（Selye和Friedman，1941; Gaarenstroom和deJongh，1946）。垂体促性腺激素的分泌显然受循环性激素的调节，
introduction1 The inhibiting effects of the male sex hormone on testis weight and spermatogenesis in the rat have been reported by numerous workers using wide ranges of doses of androgens in various ages of animals. The trend of the results, however, shows an apparently anomalous situation in that small doses of androgen (0.1 to 1.0 mg. per day) caused greater injury than large doses (2.0 to 10.0 mg. per day) (Moore and Price, 1937, 1938; Selye and Friedman, 1941; Zahler, 1944; and numerous other references listed in the bibliographies of these papers). Administration of estrogenic substances to rats likewise produced a severe suppression of testicular function which could be prevented if androgens were injected simultaneously (Selye and Friedman, 1941; Gaarenstroom and deJongh, 1946). The secretion of the gonadotrophins by the pituitary is apparently regulated by the circulating sex hormones,