ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE
ANTIBODY TO INTERLEUKIN-5 INHIBITS HELMINTH-INDUCED EOSINOPHILIA IN MICE
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DOI：
10.1126/science.2787531
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发表时间：
1989-07-21
期刊：
影响因子：
56.9
通讯作者：
RENNICK, D
中科院分区：
文献类型：
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作者：
COFFMAN, RL;SEYMOUR, BWP;RENNICK, D
当啮齿类动物感染巴西日本圆线虫时，其血液和肺中出现大量嗜酸性粒细胞，其血清免疫球蛋白E（IgE）升高。注射白细胞介素-5单克隆抗体完全抑制血嗜酸性粒细胞和嗜酸性粒细胞在肺中的寄生虫小鼠的浸润，但对血清IgE没有影响。与此相反，白细胞介素-4抗体抑制寄生虫诱导的IgE，但不是嗜酸性粒细胞增多症。这些结果表明，白细胞介素-5在体内嗜酸性粒细胞的产生是重要的，IgE和嗜酸性粒细胞的产生是由不同的细胞因子产生的CD 4-表达T细胞的TH 2亚群调节。
When rodents are infected with the nematode Nippostrongylus brasiliensis, large numbers of eosinophils appear in their blood and lungs and their serum immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to interleukin-5 completely suppressed the blood eosinophilia and the infiltration of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not the eosinophilia. These results show that interleukin-5 is important in eosinophil production in vivo and that IgE and eosinophil production are regulated by different cytokines produced by the TH2 subset of CD4-expressing T cells.