Seven-year cumulative incidence of COPD in an age-stratified general population sample
Seven-year cumulative incidence of COPD in an age-stratified general population sample
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DOI：
10.1378/chest.129.4.879
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发表时间：
2006-04-01
期刊：
影响因子：
9.6
通讯作者：
Lundbäck, B
中科院分区：
文献类型：
--
作者：
Lindberg, A;Eriksson, B;Lundbäck, B
目的：估计COPD的累积发病率和与COPD发展相关的危险因素，包括评估全球慢性阻塞性肺疾病倡议（GOLD）0期（即，呼吸道症状和正常肺功能）和COPD的发展，在一个年龄分层的一般人群样本的中年和老年人。方法：瑞典北方阻塞性肺疾病第三次调查研究队列I 1996年进行了一项调查（1919年至1920年，1934年至1935年和1949年至1950年出生的三个年龄层），5，189名受试者（88%）回答了邮寄问卷。1996年和2003年，在答复者中随机抽样（1 500名受试者）进行了检查。两次共963例受试者进行了肺量测定。根据GOLD的肺功能测定标准定义COPD。两个疾病严重程度级别，I级及以上（GOLD标准，FEV 1/FVC比值< 0.70）以及II级及以上（GOLD II标准，FEV 1/FVC比值< 0.70且FEV 1 < 80%预测值）。根据GOLD和GOLD II，COPD的7年累积发病率分别为11.0%和4.9%，与吸烟显著相关（吸烟者分别为18.8%和10.6%;戒烟者分别为10.5%和5.2%;不吸烟者分别为7.6%和1.6%）。根据GOLD，但不是根据GOLD II，COPD事件与年龄增加显著相关。大多数呼吸系统症状在研究中，进入标记事件COPD的风险增加时，在一个多变量模型中进行分析，调整confers.Conclusion：GOLD标准产生了较高的累积发病率（11.0%）相比，GOLD 11（4.9%）。吸烟，而不是性别，与COPD的发生有关。观察期开始时的大多数呼吸道症状标志着COPD发生风险增加，因此GOLD 0期分类似乎与中年和老年人相关。
Aim: To estimate the cumulative incidence of COPD and risk factors related to the development of COPD, including evaluation of the relationship between Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 0 (ie, respiratory symptoms and normal lung function) and the development of COPD, in an age-stratified general population sample of middle-aged and elderly individuals.Method: The third survey of the Obstructive Lung Disease in Northern Sweden studies cohort I (three age strata born in 1919 to 1920, 1934 to 1935, and 1949 to 1950) was performed in 1996, and 5,189 subjects (88%) responded to the postal questionnaire. Of the responders, a random sample (1,500 subjects) was invited to an examination in 1996 and in 2003. A total of 963 subjects performed spirometry on both occasions. COPD was defined according to the spirometric criteria of the GOLD. Two levels of disease severity, grade I and higher (GOLD criteria, FEV1/FVC ratio of < 0.70) and also grade II and higher (GOLD II criteria, FEV1/FVC ratio of < 0.70 and FEV1 < 80% predicted).Results: The 7-year cumulative incidence of COPD was 11.0% and 4.9%, respectively, according to GOLD and GOLD II, and was significantly related to smoking (smokers, 18.8% and 10.6%, respectively; ex-smokers, 10.5% and 5.2%, respectively; non-smokers, 7.6% and 1.6%, respectively). Incident COPD according to GOLD, but not according to GOLD II, was significantly associated with increasing age. Most respiratory symptoms at study, entry were markers increased risk for incident COPD when analyzed in a multivariate model adjusting for confounders.Conclusion: The GOLD criteria yielded a higher cumulative incidence (11.0%) compared to the GOLD 11 (4.9%). Smoking, but not gender, was associated with incident COPD. Most respiratory symptoms at the beginning of the observation period marked an increased risk for developing COPD, thus the classification GOLD stage 0 seems relevant among middle-aged and elderly persons.