Dp140: Alternatively spliced isoforms in brain and kidney
Dp140: Alternatively spliced isoforms in brain and kidney
复制标题
DOI：
10.1006/geno.1997.4905
复制
发表时间：
1997-10-01
期刊：
影响因子：
4.4
通讯作者：
Kunkel, LM
中科院分区：
文献类型：
--
作者：
Lidov, HGW;Kunkel, LM
Dp140是一种由dystrophin远端杆状结构域和羧基末端结构域组成的蛋白质，仅在脑和肾脏表达；转录起始于dystrophin内含子44中唯一的第一外显子。这两种组织都表达特定的异构体，外显子71-74和78具有不同的选择性剪接。Dp140的羧基末端结构域与全长427-BDA dystrophin的结构域完全相同，正是这个区域与骨骼肌中的“dystrophin相关蛋白”复合体相关。选择性剪接编码已被证明是蛋白质结合区的结构域；因此，这种选择性剪接可能调节Dp140与完整膜蛋白的结合。基因组DNA的Dp140第一外显子附近的5‘侧翼区含有多种转录因子结合子，其中一些可以调节神经胶质细胞特异性基因的表达。(C)1997年学术出版社。
Dp140, a protein composed of the distal rod domain and carboxy-terminal domain of dystrophin, is expressed only in brain and kidney; transcription is initiated at a unique first exon located in dystrophin intron 44. Both tissues express specific isoforms with distinct alternative splicing of exons 71-74 and 78. The carboxy-terminal domain of Dp140 is identical to that of full length 427-bDa dystrophin, and it is this region that is associated, with the ''dystrophin-associated protein'' complex in skeletal muscle. Alternative splicing encodes domains that have been shown to be protein-binding regions; thus this alternative splicing may regulate the association of Dp140 with integral membrane proteins. The 5' flanking region of genomic DNA adjacent to the Dp140 first exon contains a variety of transcription factor-binding moths, some of which could regulate neuroglial-specific gene expression. (C) 1997 Academic Press.