Palladium-catalyzed stereoselective formation of α-O-Glycosides
Palladium-catalyzed stereoselective formation of α-O-Glycosides
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DOI：
10.1021/ol071268z
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发表时间：
2007-08-02
期刊：
影响因子：
5.2
通讯作者：
Nguyen, Hien M.
中科院分区：
文献类型：
--
作者：
Schuff, Brandon P.;Mercer, Gregory J.;Nguyen, Hien M.
[图表]开发了一种钯催化立体选择性形成 α-O-糖苷的新方法。该策略依赖于钯-联芳基膦催化剂-糖供体络合来控制异头选择性。它不依赖于底物上保护基团的性质，因此无需繁琐的保护基团操作。
[GRAPHICS]A novel method for palladium-catalyzed stereoselective formation of alpha-O-glycosides has been developed. This strategy relies on the palladium-biaryl phosphine catalyst-glycal donor complexation to control the anomeric selectivity. It does not depend on the nature of the protecting groups on the substrates, thus eliminating the need for cumbersome protecting group manipulations.