Status epilepticus produces chronic alterations in cardiac sympathovagal balance
Status epilepticus produces chronic alterations in cardiac sympathovagal balance
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DOI：
10.1111/j.1528-1167.2008.01764.x
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发表时间：
2009-04-01
期刊：
影响因子：
5.6
通讯作者：
Bealer, Steven L.
中科院分区：
文献类型：
--
作者：
Metcalf, Cameron S.;Radwanski, Przemyslaw B.;Bealer, Steven L.
癫痫持续状态（SE）激活自主神经系统，在癫痫发作活动期间增加交感神经系统对心脏功能的控制。然而，SE对心脏自主调节的持久影响（可能导致癫痫发作后的死亡率）尚不清楚。因此，在SE后评估心脏功能的自主控制。使用从锂-匹鲁卡品诱导的SE或对照程序恢复1-2周后的Sprague-Dawley大鼠，我们测试了心脏的总体交感迷走神经控制、自主神经系统的交感神经和副交感神经成分的个体贡献、SE诱导交感迷走神经平衡向交感神经优势的慢性转变，这是由于副交感神经活性降低所致。压力反射对血压升高的敏感性也降低，可能是由于迷走神经激活减少所致。心脏功能自主调节的慢性改变，其特征是交感神经支配增加，发生在SE后，可能导致随后的心脏风险和死亡率增加。
Status epilepticus (SE) activates the autonomic nervous system, increasing sympathetic nervous system control of cardiac function during seizure activity. However, lasting effects of SE on autonomic regulation of the heart, which may contribute to mortality following seizure activity, are unknown. Therefore, autonomic control of cardiac function was assessed following SE.Using Sprague-Dawley rats after 1-2 weeks of recovery from lithium-pilocarpine-induced SE or control procedures, we tested overall sympathovagal control of the heart, the individual contributions of the sympathetic and parasympathetic components of the autonomic nervous system, and baroreflex sensitivity.SE induced a chronic shift in sympathovagal balance toward sympathetic dominance resulting from decreased parasympathetic activity. Baroreflex sensitivity to increased blood pressure was also decreased, likely resulting from diminished vagal activation.Chronic alterations in autonomic regulation of cardiac function, characterized by increased sympathetic dominance, occur following SE and likely contribute to subsequent increased cardiac risk and mortality.