Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model
Partially hydrolyzed guar gum alleviates hepatic steatosis and alters specific gut microbiota in a murine liver injury model
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部分水解瓜尔胶可减轻小鼠肝损伤模型中的肝脏脂肪变性并改变特定肠道微生物群
DOI：
10.1007/s00383-022-05221-z
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发表时间：
2022
影响因子：
1.8
通讯作者：
Shimono Ryuichi
中科院分区：
文献类型：
--
作者：
Fujii Takayuki;Nakayama-Imaohji Haruyuki;Tanaka Aya;Katami Hiroto;Tanaka Kazuya;Chiba Yoichi;Kawauchi Machi;Ueno Masaki;Kuwahara Tomomi;Shimono Ryuichi
目的肠道菌群通过肠-肝轴在肠衰竭相关性肝病的发生发展中起重要作用。在这里，我们调查是否部分水解瓜尔豆胶（PHGG），膳食纤维可以减轻肝损伤和调节肠道菌群在小鼠肝损伤（LI）model.MethodsLiver损伤诱导6周龄雄性C57 BL/6小鼠使用肠内液体饮食组成的肠外营养（LI组）和治疗5%PHGG（LI/PHGG组）。采用油红O和肿瘤坏死因子-α（TNF-α）标记法进行肝组织病理学检查。肠道菌群进行了检查，使用16 S rRNA基因sequencing.ResultsLipid积累显着降低，在LI /PHGG组相比，LI组。LI组TNF-α阳性细胞面积明显高于对照组。主坐标分析（PCoA）显示PHGG治疗后肠道微生物群的显著变化。线性判别分析的效果大小表明，PHGG治疗显着增加盲肠丰度ofParabacteroides.ConclusionsPHGG减轻肝损伤后小鼠肝脂肪变性。PHGG治疗的保护作用可能与盲肠中副细菌类的丰度增加有关。
PurposeThe gut microbiota, via the gut-liver axis, plays an important role in the development of intestinal failure-associated liver disease. Here, we investigated whether partially hydrolyzed guar gum (PHGG), a dietary fiber could alleviate liver damage and modulate the gut microbiota in a murine liver injury (LI) model.MethodsLiver injury was induced in 6-week-old male C57BL/6 mice using an enteral liquid diet composed of parenteral nutrition (LI group) and treated with 5% PHGG (LI/PHGG group). Liver histopathology was examined using oil red O and a tumor necrosis factor-α (TNF-α) labeling. The gut microbiota was examined using 16S rRNA gene sequencing.ResultsLipid accumulation was significantly decreased in the LI /PHGG group when compared with that of the LI group. The area of TNF-α-positive cells was significantly higher in the LI group when compared with that of the control. The principal coordinate analysis (PCoA) revealed pronounced changes in the gut microbiota after PHGG treatment. Linear discriminant analysis of effect size showed that PHGG treatment significantly increased cecal abundance ofParabacteroides.ConclusionsPHGG alleviated hepatic steatosis following liver injury in mice. The protective effect of PHGG treatment could be associated with increased abundance ofParabacteroidesin the cecum.
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