Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity
Impulse control in the dorsolateral prefrontal cortex counteracts post-diet weight regain in obesity
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DOI：
10.1016/j.neuroimage.2014.12.073
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发表时间：
2015-04-01
期刊：
影响因子：
5.7
通讯作者：
Haynes, John-Dylan
中科院分区：
文献类型：
--
作者：
Weygandt, Martin;Mai, Knut;Haynes, John-Dylan
各种研究表明，有效的治疗，以诱导短期的饮食成功的肥胖存在。然而，持续维持减轻的体重是罕见的，因为大部分患者在治疗停止时开始恢复体重。因此，从临床的角度来看，需要确定在更长的时间尺度上抵消饮食后体重恢复的因素。为了解决这个问题，我们扩展了我们以前关于肥胖症短期饮食成功的神经冲动控制机制的工作，现在研究了饮食后抵消长期体重反弹的机制。具体来说，我们在两个时间点（即12周饮食后一年随访间隔的开始（“T0”）和结束（“T12”））使用fMRI测量了延迟折扣任务期间的神经冲动控制。然后，我们测试了T0时背外侧前额叶皮层（DLPFC）的活动以及随访期间（T0 - T12）的活动变化是否与体重维持成功有关。进行的分析表明，T0时对照相关DLPFC活性与体重维持的成功程度相关。同样，行为控制措施也与维护的成功程度有关。神经和行为控制参数的预测体重变化建模的直接比较显示，神经信号更翔实。总之，在饮食后直接用fMRI测量的DLPFC中的神经冲动控制预测了肥胖患者在长时间内的饮食成功。(C)2015 Elsevier Inc. All rights reserved.
A variety of studies suggest that efficient treatments to induce short-term dietary success in obesity exist. However, sustained maintenance of reduced weight is rare as a large proportion of patients start to regain weight when treatment is discontinued. Thus, from a clinical perspective, it would be desirable to identify factors that counteract post-diet weight regain across longer time-scales. To address this question, we extended our previous work on neural impulse control mechanisms of short-term dietary success in obesity and now investigated the mechanisms counteracting long-term weight regain after a diet. Specifically, we measured neural impulse control during a delay discounting task with fMRI at two time points, i.e. the beginning ('T0') and the end ('T12') of a one-year follow-up interval after a 12-week diet. Then, we tested whether activity in the dorsolateral prefrontal cortex (DLPFC) at T0 and whether activity changes across the follow-up period (T0 - T12) are linked to success in weight maintenance. The analyses conducted show that control-related DLPFC activity at T0 was coupled to the degree of success in weight maintenance. Consistently, also behavioral measures of control were linked to the degree of success in maintenance. A direct comparison of neural and behavioral control parameters for prognostic weight change modeling revealed that neural signals were more informative. Taken together, neural impulse control in the DLPFC measured with fMRI directly after a diet predicts real-world diet success in obese patients across extended time periods. (C) 2015 Elsevier Inc. All rights reserved.