A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes.
A nonparametric test for observational non-normally distributed ophthalmic data with eye-specific exposures and outcomes.
复制标题
对具有眼睛特定暴露和结果的观察性非正态分布眼科数据进行非参数检验。
DOI：
10.1080/09286580701396704
复制
发表时间：
2007
影响因子：
1.8
通讯作者：
Lee,Mei-LingT
中科院分区：
文献类型：
--
作者：
Rosner,Bernard;Glynn,RobertJ;Lee,Mei-LingT
PurposeTo扩展的Wilcoxon秩和检验的聚类观察数据的分析与一个二进制的曝光变量，其中不是所有的集群成员（或亚单位）具有相同的曝光状态，在眼科数据中，其他眼睛可能不同的曝光status.MethodsThe Wilcoxon秩和检验统计量（WC）被定义为所有暴露的亚单位在所有集群的秩和。大样本分布的Wcis推导基于两阶段排列分布的方法，该方法保持了原始数据中暴露分布的聚类结构。该程序应用于威斯康星州糖尿病视网膜病变流行病学研究（WESDR）的数据，以评估高与低眼内压（IOP）眼之间视网膜病变等级的差异。结果基于WESDR数据的数据分析表明，如通过聚类Wilcoxon检验评估的，IOP与视网膜病变等级之间存在显著正相关（p= 0.019），但非显着影响与混合模型程序的基础上的原始scores（p= 0.30）。ConclusionsThe聚类Wilcoxon程序是一种有效的方法，用于分析聚类非正常结果数据与二元眼睛特定的曝光，可能会有所不同，在2个眼睛的个人。
PurposeTo extend the Wilcoxon rank sum test to the analysis of clustered observational data with a binary exposure variable where not all cluster members (or subunits) have the same exposure status, as in ophthalmologic data where fellow eyes may differ in exposure status.MethodsThe Wilcoxon rank sum test statistic (Wc) is defined as the sum of ranks of all exposed subunits over all clusters. The large sample distribution ofWcis derived based on a two-stage permutation distribution approach which maintains the clustering structure of the exposure distribution in the original data. The procedure is applied to data from the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) for assessing differences in retinopathy grade between eyes with high vs. low intraocular pressure (IOP).ResultsData analyses based on the WESDR data indicate significant positive associations between IOP and retinopathy grade as assessed by the clustered Wilcoxon test (p= 0.019), but non-significant effects with mixed model procedures based on raw scores (p= 0.30).ConclusionsThe clustered Wilcoxon procedure is an effective approach for analyzing clustered non-normal outcome data with a binary eye-specific exposure which may vary in 2 eyes of an individual.