Effects of suramin on complement, blood clotting, fibrinolysis and kinin formation
Effects of suramin on complement, blood clotting, fibrinolysis and kinin formation
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苏拉明对补体、凝血、纤溶和激肽形成的影响
DOI：
10.1111/j.1476-5381.1973.tb08544.x
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发表时间：
1973
影响因子：
7.3
通讯作者：
C. Loveday
中科院分区：
文献类型：
--
作者：
V. Eisen;C. Loveday
苏拉明对补体成分、凝血因子、纤溶因子和血浆激肽形成因子的抑制作用取决于试验条件和所用底物。2在红细胞悬液中，补体溶血的抑制作用比琼脂糖凝胶板中更有效。在酯水解试验中，0·1-0·3 mm苏拉明能显著抑制组分1（C1）对C1酯酶的激活，0·5 mm苏拉明能显著抑制C1酯酶的活性。3苏拉明的抗凝作用部分是由于抑制凝血酶对纤维蛋白原的作用。4苏拉明不抑制血浆纤溶系统对纤维蛋白的降解。在酯溶解试验中，纤溶酶原的激活比纤溶酶的活性更有效地抑制。5通过激肽形成或酯溶解测定的血浆激肽释放酶的激活被0.1 - 0.3 mm苏拉明抑制。0.3 - 0.5mm苏拉明可抑制血浆激肽释放酶活性。胰腺激肽释放酶受到微弱抑制，而尿激肽释放酶完全没有受到抑制。
1 The inhibition by suramin of complement components, and of blood clotting, fibrinolytic, and plasma kinin forming factors depended on the conditions of the assay and on the substrates used. 2 Haemolysis by complement was more effectively inhibited in red blood cell suspensions, than in agarose gel plates. In esterolytic tests, the activation of component 1 (C1) to C1 esterase was significantly inhibited by 0·1–0·3 mm suramin, and the activity of C1 esterase by 0·5 mm suramin. 3 Part of the anticoagulant effect of suramin is due to inhibition of the action of thrombin on fibrinogen. 4 Suramin did not inhibit fibrin degradation by the fibrinolytic system in plasma. In esterolytic tests, the activation of plasminogen was more potently inhibited than the activity of plasmin. 5 Activation of plasma kallikrein, measured either by kinin formation or by esterolysis, was inhibited by 0·1–0·3 mm suramin. Active plasma kallikrein was inhibited by 0·3–0·5 mm suramin. Pancreatic kallikrein was weakly inhibited, and urinary kallikrein not at all.