Uric acid and inflammatory markers.
Uric acid and inflammatory markers.
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DOI：
10.1093/eurheartj/ehi879
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发表时间：
2006-05
影响因子：
39.3
通讯作者：
C. Ruggiero;A. Cherubini;A. Ble;Â. Bós;M. Maggio;V. Dixit;F. Lauretani;S. Bandinelli;U. Senin-U.-Sen
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文献类型：
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作者：
C. Ruggiero;A. Cherubini;A. Ble;Â. Bós;M. Maggio;V. Dixit;F. Lauretani;S. Bandinelli;U. Senin-U.-Sen
目的尿酸(UA)在动脉粥样硬化和动脉粥样硬化形成过程中的作用存在争议。最近的流行病学研究表明，尿酸可能是心血管疾病的危险因素，也可能是既往心力衰竭患者死亡的负面预后标志。方法和结果我们评估了957名无严重肾功能衰竭的意大利65-95岁人群中尿酸水平与几种炎症标志物之间的关系。检测血浆尿酸、白细胞(WBC)、中性粒细胞计数、C反应蛋白、白介素1受体拮抗剂(IL-1ra)、白介素6(IL-6)、可溶性白介素6受体(sIL-6R)、白介素18(IL-18)、肿瘤坏死因子-α(TNF-α)。使用标准方法收集关于潜在混杂因素的完整信息。白细胞(P=0.0001)、中性粒细胞(P<；0.0001)、C反应蛋白(P<；0.0001)、IL-1ra(P<；0.0001)、IL-6(P=0.0004)、sIL-6R(P=0.002)、IL-18(P<；0.0001)、肿瘤坏死因子-α(P=0.0008)、异常高C反应蛋白(P=0.004)和IL-6(P=0.0001)的受试者在UA五分位数中显著升高。在对年龄、性别、行为和疾病相关的混杂因素进行调整后，结果几乎没有变化。在UA正常者中，UA与中性粒细胞计数、C反应蛋白、IL-6、IL-1ra、IL-18和TNF-α显著相关，而与WBC(P=0.1)和sIL-6R(P=0.2)无显著相关性。结论：在以老年人为基础的大样本和尿酸正常参与者的亚样本中，发现尿酸与几种炎症标志物之间存在显著的正相关。因此，在UA五分位数中，C反应蛋白和IL-6异常高水平的患病率显著增加。
AIMS The role of uric acid (UA) in the process of atherosclerosis and atherotrombosis is controversial. Epidemiological studies have recently shown that UA may be a risk factor for cardiovascular diseases and a negative prognostic marker for mortality in subjects with pre-existing heart failure. METHODS AND RESULTS We evaluate a relationship between UA levels and several inflammatory markers in 957 subjects, free of severe renal failure, from a representative Italian cohort of persons aged 65-95. Plasma levels of UA and white blood cell (WBC) and neutrophil count, C-reactive protein, interleukin-1 receptor antagonist (IL-1ra), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6r), interleukin-18 (IL-18), and tumor necrosis factor-alpha (TNF-alpha) were measured. Complete information on potential confounders was collected using standard methods. WBC (P=0.0001), neutrophils (P<0.0001), C-reactive protein (P<0.0001), IL-1ra (P<0.0001), IL-6 (P=0.0004), sIL-6r (P=0.002), IL-18 (P<0.0001), TNF-alpha (P=0.0008), and the percentage of subjects with abnormally high levels of C-reactive protein (P=0.004) and IL-6 (P=<0.0001) were significantly higher across UA quintiles. After adjustment for age, sex, behaviour- and disease-related confounders, results were virtually unchanged. In subjects with UA within the normal range, UA was significantly and independently associated with neutrophils count, C-reactive protein, IL-6, IL-1ra, IL-18, and TNF-alpha, whereas non-significant trends were observed for WBC (P=0.1) and sIL-6r (P=0.2). CONCLUSION A positive and significant association between UA and several inflammatory markers was found in a large population-based sample of older persons and in a sub-sample of participants with normal UA. Accordingly, the prevalence of abnormally high levels of C-reactive protein and IL-6 increased significantly across UA quintiles.