Yes, MAM!
Yes, MAM!
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DOI：
10.1080/23723556.2021.1919473
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发表时间：
2021-05-21
影响因子：
2.1
通讯作者：
Katz, Samuel G.
中科院分区：
文献类型：
--
作者：
Means, Robert E.;Katz, Samuel G.
BCL-2 蛋白家族成员对细胞生命和死亡的调节发生在线粒体。线粒体外膜的大部分与内质网 (ER) 紧密接近，称为线粒体相关膜 (MAM) 或线粒体-ER 接触位点 (MERC)。我们最近报道，BOK 存在于 MAM 中，调节 Ca2+ 从 ER 到线粒体的转移、适当的 MAM 成分和 MERC 结构以及细胞凋亡。
Regulation of cell life and death by members of the BCL-2 family of proteins occurs at the mitochondria. Large portions of the mitochondria's outer membrane are found in tight approximation with the endoplasmic reticulum (ER), known as mitochondria-associated membranes (MAMs) or mitochondria-ER contact sites (MERCs). We recently reported that BOK is present within MAMs where it regulates Ca2+ transfer from the ER to the mitochondria, appropriate MAM components and MERC structure, and apoptosis.