Evolution of cross-feeding in microbial populations
Evolution of cross-feeding in microbial populations
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DOI：
10.1086/383593
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发表时间：
2004-06-01
影响因子：
2.9
通讯作者：
Bonhoeffer, S
中科院分区：
文献类型：
--
作者：
Pfeiffer, T;Bonhoeffer, S
虽然受到单一资源的限制，但在连续培养（恒化器）中长时间生长的微生物种群经常进化出稳定的多态性。这些多态性可以通过交叉喂养来维持，其中一种菌株部分降解主要能源并分泌被第二种菌株用作能源的中间体。目前还不清楚交叉喂养菌株相对于完全降解主要资源的单一竞争对手具有什么选择优势。在这里，我们表明，交叉喂养可能会演变在微生物种群作为以下优化原则的结果：ATP生产率最大化，酶的途径的浓度最小化，和中间体的途径的浓度最小化。
Although limited by a single resource, microbial populations that grow for long periods in continuous culture (chemostat) frequently evolve stable polymorphisms. These polymorphisms may be maintained by cross-feeding, where one strain partially degrades the primary energy resource and excretes an intermediate that is used as an energy resource by a second strain. It is unclear what selective advantage cross-feeding strains have over a single competitor that completely degrades the primary resource. Here we show that cross-feeding may evolve in microbial populations as a consequence of the following optimization principles: the rate of ATP production is maximized, the concentration of enzymes of the pathway is minimized, and the concentration of intermediates of the pathway is minimized.