Developmental characteristics of urinary coproporphyrin I/(I + III) ratio.
Developmental characteristics of urinary coproporphyrin I/(I + III) ratio.
复制标题
尿粪卟啉 I/(I III) 比值的发育特征。
作者：
Kunikata J;Okada H;Itoh S;Kusaka T
尿粪卟啉（UCP）I与尿粪卟啉I和III总量的比值[UCP {I/（I+ III）]]是ATP结合盒亚家族C成员2（ABCC 2）功能的生物标志物。本研究的目的是阐明UCP [I/（I+ III）]的发育模式的特征，以便通过在整个儿童期测量UCP [I/（I + III）]来估计儿童，特别是新生儿期的ABCC 2功能。方法UCP [I/（I+ III）]的测量采用高效液相色谱法进行，使用从1天到15岁收集的儿童尿样，每个孩子一个样本结果UCP [I/（I+ III）]在6个月以内的婴幼儿中变化较大，≥ 0.3者占80%;相反，在1-2岁时降至< 0.30，最低。在0-6月龄组，出生后年龄与UCP [I/（I+ III）]无显著相关性，但校正胎龄与UCP [I/（I + III）]呈中度负相关。这表明ABCC 2活性与校正的胎龄相关，并且在1-2岁时最高。
Background The ratio of urinary coproporphyrin (UCP) I to total urinary coproporphyrin I and III [UCP {I/(I+ III)]] serves as a biomarker of the ATP‐binding cassette, sub‐family C, member 2 (ABCC2) function. The aim of this study was to clarify the characteristics of the developmental pattern of UCP [I/(I+ III)] in order to estimate ABCC2 function in children, especially in the neonatal period, by measuring it throughout the entirety of childhood.Method Measurement of UCP [I/(I+ III)] was done high‐performance liquid chromatography, using urine samples collected from children from 1 day to 15 years old, involving one sample per child. Urine samples from children with liver and kidney disease and urinary tract infection were excluded.Results UCP [I/(I+ III)] varied widely in infants younger than 6 months old, and was≥ 0.3 in 80% of the infants. In contrast, it decreased to< 0.30, the lowest, at 1–2 years old. In the 0–6‐month‐old group, no significant correlation was noted between postnatal age and UCP [I/(I+ III)], but a moderate inverse correlation was noted between corrected gestational age and UCP [I/(I+ III)].Conclusion UCP [I/(I+ III)] is inversely correlated with corrected gestational age and is lowest at 1–2 years old. This suggests that ABCC2 activity is correlated with corrected gestational age and is highest at 1–2 years old.