Urinary excretion of biopyrrins, oxidative metabolites of bilirubin, increases in patients with psychiatric disorders
Urinary excretion of biopyrrins, oxidative metabolites of bilirubin, increases in patients with psychiatric disorders
复制标题
DOI：
10.1016/j.euroneuro.2004.11.002
复制
发表时间：
2005-05-01
影响因子：
5.6
通讯作者：
Horiguchi, J
中科院分区：
文献类型：
--
作者：
Miyaoka, T;Yasukawa, R;Horiguchi, J
一些作者认为，心理应激诱导活性氧（ROS）的产生。几项研究支持胆红素在体内发挥抗氧化作用的观点，并且据报道，心理应激引起体内胆红素氧化[Yamaguchi T.，盐路岛，杉本A.山冈M.，2002.心理应激增加人体尿液中胆红素代谢产物。生物化学和生物物理学通信资源293，517-520]。我们研究了胆红素氧化代谢产物（生物吡咯）的浓度是否增加，从精神疾病患者的尿液。对25例精神疾病患者（精神分裂症，15例;抑郁症，10例）和96例健康志愿者尿液中的生物吡啉浓度进行了比较。将通过酶联免疫吸附测定法测量的生物吡咯的浓度归一化为尿肌酐浓度。精神疾病（精神分裂症和抑郁症）患者的biopynins浓度显著高于健康志愿者。在精神分裂症患者中，生物比林水平与简明精神病评定量表（BPRS）评分相关，在抑郁症患者中，生物比林水平与汉密尔顿抑郁评定量表（HAM-D）评分相关。这些发现表明，精神病状态与人尿中胆红素氧化代谢产物的增加有关。(c)2004年Elsevier B.V和ECNP。All rights reserved.
Several authors have suggested that psychological stress induces the production of reactive oxygen species (ROS). Several studies have supported the idea that bilirubin exerts antioxidative effects in vivo, and it was reported psychological stress provokes bilirubin oxidation in vivo [Yamaguchi T., Shioji I., Sugimoto A., Yamaoka M., 2002. Psychological stress increases bilirubin metabolites in human urine. Biochem. and Biophys. Res. Commun. 293, 517-520]. We investigated whether the concentration of bilirubin oxidative metabolites (biopyrrins) is increased in urine from patients with psychiatric disorders. The concentration of biopyrrins in urine of 25 patients with psychiatric disorders (schizophrenia, 15; depression, 10) was compared with 96 healthy volunteers. The concentrations of biopyrrins, as measured by enzyme-linked immunosorbent assay, were normalized to the urinary concentration of creatinine. The concentration of biopynins in patients with psychiatric disorders (schizophrenia and depression) was significantly higher than that of healthy volunteers. In schizophrenia, biopyrrins levels correlated with scores of the Brief Psychiatric Rating Scale (BPRS), and in depression, biopyrrins levels correlated with scores of the Hamilton Depression Rating Scale (HAM-D). These finding suggest that psychotic states are associated with an increase in the oxidative metabolites of bilirubin in human urine. (c) 2004 Elsevier B.V and ECNP. All rights reserved.