Emerging design principles in Biomaterials and scaffolds for tissue engineering
Emerging design principles in Biomaterials and scaffolds for tissue engineering
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DOI：
10.1111/j.1749-6632.2002.tb03056.x
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发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Griffith, LG
中科院分区：
文献类型：
--
作者：
Griffith, LG
生物材料和支架在组织工程中起着重要的作用，可以在体内和体外引导新组织生长。虽然现有外科材料的适应性已经满足了该领域的一些需求，但新的应用需要更好地控制本体性质，如降解和控制细胞相互作用的表面性质。分子细胞生物学的进展正在推动新的生物部分纳入材料，一套基于定量分析再生中涉及的关键细胞过程的设计原则正在出现。与此同时，新的材料加工方法正在出现，可以将这些脆弱的材料制成适合运送的装置。
Biomaterials and scaffolds play an essential role in tissue engineering by guiding new tissue growth in vivo and in vitro. While adaptation of existing surgical materials has fulfilled some needs in the field, new applications demand better control of bulk properties such as degradation and of surface properties that control cell interactions. Advances in molecular cell biology are driving the incorporation of new biological moieties into materials, and a set of design principles based on quantitative analysis of key cellular processes involved in regeneration is emerging. At the same time, new materials-processing methodologies are emerging to allow fabrication of these fragile materials into devices appropriate for delivery.