Recognition of eukaryotic promoters using a genetic algorithm based on iterative discriminant analysis
Recognition of eukaryotic promoters using a genetic algorithm based on iterative discriminant analysis
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发表时间：
2003
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通讯作者：
V. Levitsky;A. Katokhin
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作者：
V. Levitsky;A. Katokhin
提出了一种识别真核基因启动子区的新方法，并以果蝇为例进行了说明。其新奇的本质是在实现的遗传算法，以搜索最佳分区的启动子区域到本地的非重叠片段和选择的最显着的二核苷酸频率的片段获得。将该方法应用于识别果蝇基因的TATA启动子（TATA+）和DPE启动子（DPE+）。启动子识别程序包括在GeneExpress系统RegScan部分（http：//wwwmgs.bionet.nsc.ru/mgs/programs/proga/）中。
A new approach to recognizing promoter regions of eukaryotic genes is proposed and illustrated by an example of Drosophila melanogaster. The essence of its novelty is in realizing the genetic algorithm to search for optimal partition of a promoter region into local nonoverlapping fragments and selection of the most significant dinucleotide frequencies for the fragments obtained. The method developed was applied to recognizing TATA-containing (TATA+) and DPE-containing (DPE+) promoters of Drosophila melanogaster genes. The program for promoter recognition is included into the GeneExpress system, section RegScan (http://wwwmgs.bionet.nsc.ru/mgs/programs/proga/).