Retrospective comparison of outcomes of laparoscopic and open surgery for T2 gallbladder cancer - Thirteen-year experience
Retrospective comparison of outcomes of laparoscopic and open surgery for T2 gallbladder cancer - Thirteen-year experience
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DOI：
10.1016/j.suronc.2019.05.007
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发表时间：
2019-06-01
影响因子：
2.3
通讯作者：
Choi, YoungRok
中科院分区：
文献类型：
--
作者：
Jang, Jae Yool;Han, Ho-Seong;Choi, YoungRok
背景：本研究的目的是比较13年来腹腔镜手术和开腹手术治疗T2期胆囊癌的疗效。方法：回顾分析2004年4月至2017年4月间收治的247例T2期胆囊癌患者，其中病理分期为T2期的151例。将患者分为腹腔镜组(LS组)和开腹组(OS组)。结果：LS组55例和OS组44例符合纳入标准。两组术后并发症发生率相似(12.7%vs13.6%，P=1.000)。LS组术后平均住院天数显著缩短(5.8vs9.5d，p<；0.001)。LS组无瘤生存率明显高于LS组(P=0.0171)。LS组和OS组的T2N0(p=0.107)和T2N1患者(p=0.969)的无病生存率差异无统计学意义。两组总存活率无显着性差异(p=0.116)。LS组和OS组的T2N0(p=0.0941)和T2N1(p=0.579)患者的总生存率也无显著差异。结论：腹腔镜手术治疗T2胆囊癌在无病生存率、总生存率和并发症发生率方面与开腹手术相似。未来应该进行更多患者的前瞻性研究，以证实这一结果。
Background: The objective of this retrospective study is to compare the outcomes of laparoscopic and open surgery for T2 gallbladder cancer (GBC) performed a our hospital for last 13 years.Methods: Of 247 GBC patients who were treated a our hospital between Apr 2004 and Apr 2017, 151 patients with pathologic stage T2 were reviewed. Patients were divided into laparoscopic surgery group (LS group) and open (OS group). Medical recordings were reviewed to check perioperative outcomes, overall survival rates, and disease free survival rates.Results: Fifty-five patients in LS group and 44 in OS met the inclusion criteria. Incidences of postoperative complication were similar between two groups (12.7% vs 13.6%, p = 1.000). Average postoperative hospital stay was significantly shorter in LS group (5.8 vs 9.5 days, p < 0.001). LS group showed significantly higher disease free survival rate (p = 0.0171). There was no significant difference in terms of disease free survival between T2N0 (p = 0.107) and T2N1 patients (p = 0.969) of LS group and OS group. In terms of overall survival rate there was no significant difference (p = 0.116). Overall survival rate was also not significantly different between T2N0 (p = 0.0941) and T2N1 (p = 0.579) patients of LS group and OS group.Conclusions: Laparoscopic approach for treatment of T2 GBC was comparable to open approach in terms of disease free survival, overall survival and complication rate. Further prospective study with higher number of patients should be done to confirm this result in the future.