Bioinformatics approaches to quadruplex sequence location
Bioinformatics approaches to quadruplex sequence location
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DOI：
10.1016/j.ymeth.2007.08.004
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发表时间：
2007-12-01
期刊：
影响因子：
4.8
通讯作者：
Todd, Alan K.
中科院分区：
文献类型：
--
作者：
Todd, Alan K.
鸟嘌呤四链体结构是潜在有用的治疗靶标。已经有几项研究试图定位能够形成这些结构的基因组序列。由于已经鉴定的潜在四链体形成序列的数量如此之高，因此已经应用了几种不同的策略来尝试和确定这些序列中的哪些可能是生理相关的以及哪些序列最有可能形成四链体结构。这些都是基于有限的结构信息，目前可用的和比较分析的位置，这些序列相对于不同的基因组区域。序列信息本身不足以鉴定参与四链体结构的核酸区域，然而，当与进一步的实验补充时，它是发现四链体结构的起点。(c)2007爱思唯尔公司All rights reserved.
Guanine quadruplex structures are potentially useful therapeutic targets. There have been several studies attempting to locate genomic sequences which are capable of forming these structures. Since the number of potential quadruplex forming sequences which have been identified is so high, several different strategies have been applied to try and determine which of these sequences may be physiologically relevant and which sequences are most likely to form quadruplex structures. These are based on the limited structural information that is currently available and comparative analyses of the location of these sequences with respect to different genomic regions. Sequence information alone is not enough to identify regions of nucleic acid which participate in quadruplex structures, however it is the starting point for quadruplex structure discovery when complemented with further experimentation. (c) 2007 Elsevier Inc. All rights reserved.