Pregnant Individuals' Views on Fetal Tissue Research in the United States.
Pregnant Individuals' Views on Fetal Tissue Research in the United States.
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孕妇对美国胎儿组织研究的看法。
DOI：
10.1097/aog.0000000000004576
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发表时间：
2021-11-01
影响因子：
7.2
通讯作者：
Lyerly AD
中科院分区：
文献类型：
--
作者：
Spach NC;Jaffe EF;Sullivan KA;Goldfarb IT;Anderson JR;Coleman J;Gilbert SZ;Gross MS;Rahangdale L;Faden RR;Lyerly AD
胎儿组织研究推动了医学的重大进步，但在美国仍然存在公开争议。美国孕妇对胎儿组织捐赠的看法为这个问题提供了一个重要的、以前未被探索过的观点。我们对两项独立的更广泛的定性研究的数据进行了二次分析。使用半结构化指南对来自北卡罗来纳大学教堂山分校、约翰霍普金斯大学和马萨诸塞州总医院临床中心的孕妇和最近怀孕的个体 (n=79) 进行了单独访谈，该指南解决了与传染病研究和怀孕相关的一系列问题，包括胎儿组织研究的可接受性。采访内容经过转录、编码和分析，以找出新出现的主题。在这个主要由黑人（61%）、育龄孕妇和最近怀孕的参与者组成的样本中，大多数（72%）普遍支持胎儿组织研究。确定了以下三个主题：选择、尊重和意义。受访者深入讨论了有关胎儿组织研究的决策的个人性质，强调知情同意的重要性以及在寻求同意时尊重个人情绪状态的重要性。参与者看待如何尊重地处理胎儿组织的方式也塑造了对捐赠可接受性的看法，无论是支持还是反对。对于许多参与者来说，胎儿组织捐赠给研究代表了赋予终止或流产意义的一种方式。在这些怀孕和最近怀孕的个体的不同样本中，大多数人支持胎儿组织捐赠用于研究。更好地了解孕妇对此主题的看法可能会导致制定与面临胎儿遗骸处置决定的人们的需求和价值观相一致的政策和做法。在怀孕和最近怀孕的不同样本中，大多数人支持胎儿组织捐赠用于研究，理由是选择、尊重和意义。
Fetal tissue research has driven significant medical advances but remains publicly contentious in the United States. The views of pregnant individuals in the U.S. regarding the donation of fetal tissue offer an important and previously unexplored perspective on this issue. We conducted a secondary analysis of data from two separate broader qualitative studies. Pregnant and recently pregnant individuals (n=79) from clinical sites at the University of North Carolina at Chapel Hill, Johns Hopkins University, and Massachusetts General Hospital were interviewed individually using a semi-structured guide addressing a range of issues related to infectious disease research and pregnancy, including the acceptability of fetal tissue research. Interviews were transcribed, coded, and analyzed for emergent themes. Among this sample of predominantly Black (61%), reproductive-aged pregnant and recently pregnant participants, the majority (72%) generally supported fetal tissue research. The following three themes were identified: choice, respect, and meaning. Respondents discussed deeply personal nature of decisions surrounding fetal tissue research, emphasizing the importance of informed consent and respect for the person’s emotional state when approaching for consent. The ways in which participants regarded how to respectfully handle fetal tissue also shaped views about the acceptability of donation, both for and against. For many participants, fetal tissue donation to research represented one way of ascribing meaning to pregnancy termination or loss. Among this diverse sample of pregnant and recently pregnant individuals, most were supportive of fetal tissue donation for research. A better understanding of pregnant individuals’ views on this topic may lead to policies and practices that are congruent with the needs and values of people facing decisions regarding the disposition of fetal remains. Among a diverse sample of pregnant and recently pregnant individuals, most were supportive of fetal tissue donation for research, citing choice, respect and meaning.