A comprehensive genetic map of the human genome based on 5,264 microsatellites
A comprehensive genetic map of the human genome based on 5,264 microsatellites
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DOI：
10.1038/380152a0
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发表时间：
1996-03-14
期刊：
影响因子：
64.8
通讯作者：
Weissenbach, J
中科院分区：
文献类型：
--
作者：
Dib, C;Faure, S;Weissenbach, J
近年来在一些高等真核生物中成功的连锁研究的大量增加基本上是由于参考遗传连锁图谱(1-6)的重大改进，目前该图谱包括简单序列或微卫星的短串联重复序列多态(7，8)。我们在此报告Genethon人类连锁图谱的最新版本(6)。该图谱由5,264个短串联(AC/TG)(N)重复序列组成，平均杂合度为70%。该图谱的性别平均遗传距离为3,699厘米，包含2,335个位置，其中2,032个位置可以以至少1,000：1的赔率对替代顺序进行排序。平均间隔大小为1.6 cm；59%的地图最多被2 cm的间隔覆盖，1%的地图保持在10 cm以上的间隔。
The great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps(1-6), which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites(7,8). We report here the last version of the Genethon human linkage map(6). This map consists of 5,264 short tandem (AC/TG)(n) repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.