Serum xanthine oxidase in human liver disease
Serum xanthine oxidase in human liver disease
复制标题
人类肝脏疾病中的血清黄嘌呤氧化酶
DOI：
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发表时间：
2001
影响因子：
9.8
通讯作者：
F. Stirpe
中科院分区：
文献类型：
--
作者：
M. Battelli;S. Musiani;M. Valgimigli;L. Gramantieri;F. Tomassoni;L. Bolondi;F. Stirpe
目的：高浓度血清黄嘌呤氧化酶（XO）在人类肝脏疾病和肝细胞损伤的实验环境中已被报道。然而，尚不清楚这种升高是否反映肝细胞坏死或有不同的含义。方法：采用竞争性ELISA法检测64例慢性肝病患者（17例肝硬化患者，30例慢性肝炎患者，17例胆汁淤积症患者）和12例对照者的血清XO水平。对所有患者进行常规血清肝损伤标志物评估，并根据Knodell对慢性肝炎组进行分级和分期。结果：患者血清XO水平明显高于对照组。当对照组分别与慢性肝炎和胆汁淤积症患者进行比较时，差异也很显著，但与肝硬化组相比则没有显著差异。胆汁淤积紊乱患者的XO值高于肝硬化或慢性肝炎患者。慢性肝炎组XO水平与分期、分级无相关性。我们发现患者血清XO水平与γ-谷氨酰转肽酶呈微弱但显著的正相关（r = 0.37）。当分别检测慢性肝炎（r = 0.42）和胆汁淤积障碍（r = 0.71）时，这种相关性更强，但在肝硬化组中不存在这种相关性。胆汁淤积症患者的XO值与碱性磷酸酶呈正相关。在我们的研究人群中，血清XO bbb32 μg/ml特异性鉴定出胆汁淤积性疾病。结论：慢性肝病患者血清XO的显著升高似乎反映了胆汁淤积的存在。在这些患者中没有发现XO水平与肝细胞坏死的组织学或血清证据之间的相关性。
OBJECTIVES:High concentrations of serum xanthine oxidase (XO) have been reported during human liver disease and hepatocyte injury in experimental settings. However, it is unclear whether this elevation reflects hepatocyte necrosis or has a different meaning.METHODS:The serum level of XO in 64 patients with chronic liver disease (17 patients with cirrhosis, 30 with chronic hepatitis, and 17 with cholestatic disorders) and in 12 control subjects was determined by a competitive ELISA. Conventional serum markers of liver damage were assessed in all patients, and grading and staging were scored in the chronic hepatitis group according to Knodell.RESULTS:The XO serum levels were significantly higher in the patients than in the controls. The differences were also significant when controls were compared to patients with chronic hepatitis and cholestatic disorders separately, but not when compared to the cirrhosis group. Patients with cholestatic disorders had XO values higher than those of patients with cirrhosis or chronic hepatitis. XO levels did not correlate with stage and grade in chronic hepatitis group. We found a weak but significant positive correlation in patients between XO serum level and γ-glutamyl transpeptidase (r = 0.37). This correlation was stronger when chronic hepatitis (r = 0.42) and, especially cholestatic disorders (r = 0.71), were separately tested, but was absent in the cirrhosis group. The XO values positively correlated with alkaline phosphatase in patients with cholestatic disorders. A level of serum XO >32 μg/ml specifically identified cholestatic disorders in our study population.CONCLUSIONS:A marked elevation of serum XO in patients with chronic liver disease seems to reflect the presence of cholestasis. No correlation between XO levels and histological or serum evidence of hepatocyte necrosis was found in these patients.
DOI：
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发表时间：
1990
期刊：
The American journal of pathology
影响因子：
--
作者：
Friedl,HP;Smith,DJ;Till,GO;Thomson,PD;Louis,DS;Ward,PA
通讯作者：
Ward,PA
循环黄嘌呤氧化酶：缺血性损伤的潜在介质。
DOI：
10.1152/ajpgi.1990.258.4.g564
发表时间：
1990
期刊：
The American journal of physiology
影响因子：
--
作者：
Yokoyama,Y;Beckman,JS;Beckman,TK;Wheat,JK;Cash,TG;Freeman,BA;Parks,DA
通讯作者：
Parks,DA
失血小鼠的血浆通过黄嘌呤氧化酶依赖性机制激活 CREB 并增加肺单核细胞中的细胞因子表达。
DOI：
10.1165/ajrcmb.14.2.8630271
发表时间：
1996
期刊：
American journal of respiratory cell and molecular biology.
影响因子：
--
作者：
Shenkar,R;Abraham,E
通讯作者：
Abraham,E