A domain mosaic model of the skin barrier.
A domain mosaic model of the skin barrier.
复制标题
皮肤屏障的域镶嵌模型。
DOI：
10.2340/000155557416
复制
发表时间：
1994
影响因子：
3.6
通讯作者：
B. Forslind
中科院分区：
文献类型：
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作者：
B. Forslind
皮肤屏障主要保护身体免受不受控制的水分流失，此外还防止水和环境物质随意进入生命系统。当前皮肤屏障的概念表明渗透性由亲水性和疏水性“通道”控制。为了解释屏障功能以及穿过该屏障的亲水性和疏水性途径，我们提出了一种新模型，“皮肤屏障的域镶嵌模型”，该模型将大部分脂质描述为分离成由“晶粒边界”界定的结晶/凝胶域，其中脂质处于流体结晶状态。这种布置提供了有效的“防水”屏障，其允许微小且受控的水分损失以保持角质细胞湿润。此外，该模型还提供了必要的机械特性，允许在皮肤表面施加弯曲和应力。此外，“颗粒边界”的流体特征代表脂质和疏水性分子可以在下坡梯度上扩散通过系统的区域。这表明，在结晶域之间的边界区域中，由于渗透促进剂可能会发生脂质组织的结构转变，而结晶相或凝胶相中脂质的整体组织不会发生结构变化。
The skin barrier primarily protects the body against uncontrolled loss of water and in addition prevents water and matter of the environment from indiscriminately entering the living system. The current concept of the skin barrier suggests that permeability is governed by a hydrophilic and a hydrophobic "channel". To account both for the barrier function and the hydrophilic and hydrophobic pathways through this barrier, we propose a new model, "the domain mosaic model of the skin barrier", which depicts the bulk of the lipids as segregated into crystalline/gel domains bordered by "grain borders" where lipids are in the fluid crystalline state. Such an arrangement provides for an effective "water-tight" barrier that allows a minute and controlled loss of water to keep the corneocytes moistened. In addition the model provides for the necessary mechanical properties permitting bending and stress imposed on the skin surface. Furthermore, the fluid character of the "grain borders" represents areas where lipid and hydrophobic molecules may diffuse through the system on down-hill gradients. It is suggested that in the border areas between the crystalline domains, structural transformations of the lipid organization due to permeation promoters may take place without structural changes in the bulk organization of lipids in the crystalline or gel phase.