Reproducibility of single-sample clearance of 99mTc-mercaptoacetyltriglycine and 131I-orthoiodohippurate.
Reproducibility of single-sample clearance of 99mTc-mercaptoacetyltriglycine and 131I-orthoiodohippurate.
复制标题
99mTc-巯基乙酰基三甘氨酸和 131I-正碘马尿酸盐的单样品清除率的重现性。
DOI：
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发表时间：
1999
影响因子：
9.3
通讯作者：
E. Dubovsky
中科院分区：
文献类型：
--
作者：
C. Russell;E. Dubovsky
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最近的文献质疑99mTC-巯基乙酰甘氨酸(MAG3)清除量的测量是否具有足够的重复性，可用于常规的临床肾功能监测。多年来，我们经常使用放射性核素成像和清除量测量相结合的方法来跟踪观察脊髓损伤患者的肾功能。
方法
在这项研究中，我们回顾了自1990年以来使用~(131)I-马尿酸(OIH)和自1991年以来使用MAG3对197名截瘫或四肢瘫痪患者进行的1626次有效肾血浆流量(ERPF)测量。将MAG3间隙除以0.53，以将其转换为ERPF。重复性由单个患者的ERPF与时间的线性回归线合并的SD来衡量。
结果与结论
MAG3组(SD=46mL/min，n=907)与OIH组(SD=52mL/min，n=719)比较，差异无统计学意义。因此，将这些数据组合起来，得到单次ERPF测量的标准偏差，即49毫升/分钟。该方法的变异系数为581mL/min平均值的8.5%。根据我们的经验，这足以监测这些患者的肾功能。
UNLABELLED
Recent literature has questioned whether 99mTc-mercaptoacetyltriglycine (MAG3) clearance measurements are reproducible enough for routine clinical monitoring of renal function. For many years, we have routinely followed the renal function of patients with spinal cord injuries using a combination of radionuclide imaging and clearance measurement.
METHODS
In this study, we retrospectively review 1626 effective renal plasma flow (ERPF) measurements in 197 patients with paraplegia or quadriplegia performed over a 21-y period, using 131I-orthoiodohippurate (OIH) through 1990 and MAG3 since 1991. MAG3 clearance was divided by 0.53 to convert it to ERPF. Reproducibility was measured as pooled SD from the single-patient linear regression lines of ERPF versus time.
RESULTS AND CONCLUSION
There was no significant difference between MAG3 (SD = 46 mL/min, n = 907) and OIH (SD = 52 mL/min, n = 719). The data were therefore combined to obtain the SD for a single ERPF measurement, which was 49 mL/min. The corresponding coefficient of variation was 8.5% of the mean value of 581 mL/min. In our experience, this is adequate for monitoring the renal function of these patients.