RISK-FACTORS FOR COMMUNITY-ACQUIRED AND HOUSEHOLD-ACQUIRED PERTUSSIS DURING A LARGE-SCALE OUTBREAK IN CENTRAL WISCONSIN
RISK-FACTORS FOR COMMUNITY-ACQUIRED AND HOUSEHOLD-ACQUIRED PERTUSSIS DURING A LARGE-SCALE OUTBREAK IN CENTRAL WISCONSIN
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DOI：
10.1093/infdis/157.6.1134
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发表时间：
1988-06-01
影响因子：
6.4
通讯作者：
DAVIS, JP
中科院分区：
文献类型：
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作者：
BIELLIK, RJ;PATRIARCA, PA;DAVIS, JP
为了确定与社区和家庭获得性百日咳相关的风险因素，我们研究了 61 个成员患有培养阳性疾病的家庭 (HH)，并将其特征与 58 个社区对照 HH 和 62 个随机选择的对照 HH 进行了比较。与任一对照组相比，病例家庭的成员年龄在 12-18 岁之间的可能性更大 (P < .01)；这些人占所有原发病例的 34%。家庭外接触史是社区获得性感染的最重要预测因素 (P < .001)，青少年的风险高于其他年龄组（比值比，3.2；P < .001）。在同一家庭中已知接触培养阳性病例后，患病风险与年龄无关；长时间延迟开始红霉素治疗和预防是与继发性传播相关的唯一因素 (P < .01)。百日咳的风险可能更多地与接触的可能性相关，而不是与年龄相关的易感性增加相关，并且适当使用红霉素可以降低风险。
To identify risk factors associated with community- and household-acquired pertussis, we studied 61 households (HHs) with members with culture-positive illnesses and compared their characteristics with 58 neighborhood control-HHs and 62 randomly selected control-HHs. Case-HHs were more likely than either control group to have members 12-18 y of age (P < .01); these individuals accounted for 34% of all primary cases. A history of exposure outside the home was the most important predictor of community-acquired infection (P < .001), with adolescents being at higher risk than other age-groups (odds ratio, 3.2; P < .001). After known exposure to a culture-positive case in the same HH, the risk of illness was unrelated to age; lengthy delays in initiating erythromycin therapy and prophylaxis were the only factors associated with secondary spread (P < .01). The risk of pertussis may be related more to the likelihood of exposure than to age-related increases in susceptibility, and the risk can be reduced with appropriate use of erythromycin.