Properties of an injectable low modulus PMMA bone cement for osteoporotic bone
Properties of an injectable low modulus PMMA bone cement for osteoporotic bone
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DOI：
10.1002/jbm.b.31044
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发表时间：
2008-08-01
影响因子：
3.4
通讯作者：
Schneider, Erich
中科院分区：
文献类型：
--
作者：
Boger, Andreas;Bohner, Marc;Schneider, Erich
使用聚甲基丙烯酸甲酯（PMMA）骨水泥加固脆弱或断裂的椎体（椎体成形术）会导致广泛的骨硬化。相邻椎骨的骨折可能是这种手术的结果。具有降低的杨氏模量的PMMA可能更合适。本研究的目的是生产和表征刚度适应性PMMA骨水泥。通过将PMMA与不同体积分数的透明质酸钠水溶液组合来制备多孔PMMA骨水泥。研究了这些多孔水泥的孔隙率、杨氏模量、屈服强度、聚合温度、凝固时间、粘度、可注射性和单体释放。样品呈现直径在25-260 μ m范围内的孔隙，孔隙率高达56%。杨氏模量和屈服强度分别从930下降到50 MPa和从39下降到1.3 MPa之间的0和56%的孔隙率。聚合温度从68 ℃（0%，常规水泥）降低到具有30%含水部分的水泥的41 ℃。凝固时间从1020 s（0%，普通水泥）下降到720 s的30%的组合物。30%组合物的粘度（145 Pa·s）高于从常规水泥和45%组合物获得的粘度（100-125 Pa·s）。对于所有孔隙率，单体释放量均在4-10 mg/mL范围内;显示多孔材料的释放量没有更高。使用水性凝胶生成孔似乎是一种有前途的方法，可以使PMMA骨水泥更具顺应性，并将其机械性能降低至接近松质骨的值。(c)2008 Wiley Periodicals，Inc.
The use of polymethylmethacrylate (PMMA) cement to reinforce fragile or broken vertebral bodies (vertebroplasty) leads to extensive bone stiffening. Fractures in the adjacent vertebrae may be the consequence of this procedure. PMMA with a reduced Young's modulus may be more suitable. The goal of this study was to produce and characterize stiffness adapted PMMA bone cements. Porous PMMA bone cements were produced by combining PMMA with various volume fractions of an aqueous sodium hyaluronate solution. Porosity, Young's modulus, yield strength, polymerization temperature, setting time, viscosity, injectability, and monomer release of those porous cements were investigated. Samples presented pores with diameters in the range of 25-260 mu m and porosity up to 56%. Young's modulus and yield strength decreased from 930 to 50 MPa and from 39 to 1.3 MPa between 0 and 56% porosity, respectively. The polymerization temperature decreased from 68 degrees C (0%, regular cement) to 41 degrees C for cement having 30% aqueous fraction. Setting time decreased from 1020 s (0%, regular cement) to 720 s for the 30% composition. Viscosity of the 30% composition (145 Pa s) was higher than the ones received from regular cement and the 45% composition (100-125 Pa s). The monomer release was in the range or 4-10 mg/mL for all porosities; showing no higher release for the porous materials. The generation of pores using an aqueous gel seems to be a promising method to make the PMMA cement more compliant and lower its mechanical properties to values close to those of cancellous bone. (c) 2008 Wiley Periodicals, Inc.