Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4+2] Annulation of 2H-Isoindole Derivatives with Internal Alkynes
Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4+2] Annulation of 2H-Isoindole Derivatives with Internal Alkynes
复制标题
钯催化分子间 Heck 型脱芳香剂 [4 2] 2H-异吲哚衍生物与内部炔烃的环化
DOI：
10.1021/acs.orglett.0c01643
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Liu Lu
中科院分区：
文献类型：
--
作者：
Yao Tengfei;Zhang Fang;Zhang Junliang;Liu Lu
本研究开发了一种有趣的钯催化的分子间hek型脱芳[4 + 2]环，具有内炔的2h -异吲哚衍生物，以较高的收率提供了多种多环吡咯烷支架。该反应是2h -异吲哚转化的有效方法。
Here, an interesting palladium-catalyzed intermolecular Heck-type dearomative [4 + 2] annulation of 2H-isoindole derivatives with internal alkynes has been developed, affording diverse polycyclic pyrrolidine scaffolds in good yield. This reaction is a useful method for the transformation of 2H-isoindole.